Pediatric Oncology Group

A phase 2 pharmacokinetic and pharmacodynamic dose-finding study of oral NEPA for chemotherapy-induced nausea and vomiting in pediatric patients with cancer

Chemotherapy-induced nausea and vomiting (CINV) remains a significant challenge in pediatric oncology, with limited data guiding optimal antiemetic regimens. This phase 2 study evaluated pharmacokinetics (PK), pharmacodynamics, efficacy, and safety of oral netupitant combined wit...

Children With Synpolydactyly Type I Homozygous HOXD13 Mutations: Embryology and Surgical Correction of the “Cupping” of the Hands and Feet

PURPOSE: Some patients with familial Synpolydactyly Type I have severe flexion deformities of the hands and feet at the metacarpophalangeal and the metatarsophalangeal joints, and the resulting deformity has been named "cupping" of the hands and feet. Severe "cupping" requiring s...