Pearson (United States)

Beyond binary: mapping the evolution of melanoma across a discrete gradient of acquired chemoresistance

Abstract Models of acquired MultiDrug Resistance (MDR) in cancer commonly employ binary comparisons of MDR to treatment naïve cohorts. While convenient, this paradigm also oversimplifies the dynamic process of acquiring MDR as cellular processes (and corresponding therapies targe...

Biomechanical responses to increased longitudinal bending stiffness differ between novice and experienced runner profiles

Carbon-plated footwear has primarily been developed and evaluated in trained or competitive runners. However, whether novice runners exhibit similar biomechanical responses to increased longitudinal bending stiffness (LBS) as experienced runners remains unclear. Therefore, the pu...