Pavlov Institute of Physiology of the Russian Academy of Sciences

Local Glucocorticoid Metabolism in Post-traumatic Stress Disorder: The Emerging Role of 11-hydroxysteroid Dehydrogenases

Post-traumatic stress disorder (PTSD) is a complex psychiatric condition arising from exposure to severe trauma, characterized by intrusive memories, avoidance, negative alterations in cognition and mood, and hyperarousal.Despite advances in understanding its neurobiology, effect...

The Probiotic Strain Hafnia Alvei HA4597 and Its Protein Extract Selectively Activate Membrane Digestive Enzymes of Intestinal Cells in Mice

Oral supplementation of the Hafnia alvei (H. alvei) HA4597 probiotic strain has been shown to reduce appetite, body weight and fat content in overweight humans and obese mice. However, it remains unknown if H. alvei may also influence the gut digestive function. Thus, in the pres...

Melanocortin Receptor Signaling Modulates Anti-Obesity and Glucose Tolerance Effects of Hafnia alvei 4597 Probiotic Strain in Mice

The present study aimed to elucidate whether the metabolic effects of the probiotic bacterium Hafnia alvei 4597 depend on melanocortin receptor (MCR) signaling. The response to a 3-week intragastric treatment with the H. alvei bacterial suspension or total protein extract was com...