Pauls Stradiņš Clinical University Hospital

Depressive symptoms and fatigue are independently associated with myasthenia gravis-specific quality of life beyond neurological severity: a cross-sectional study

Neurological examination and myasthenia gravis (MG)-specific functional scales may not fully capture the psychological and fatigue-related burden of MG. This cross-sectional registry-based study included 75 adults with MG. Depressive and anxiety symptoms were assessed using the P...

Suspected Type II Kounis Syndrome with Coronary Dissection Extending from the Distal Left Main into the Proximal Left Anterior Descending Artery After Wasp Sting Anaphylaxis: A Case Report

Kounis syndrome is an acute coronary syndrome occurring in temporal association with an allergic or anaphylactic reaction. Recognition may be particularly challenging in patients with established coronary artery disease, in whom hypersensitivity-mediated mechanisms may coexist wi...

Hereditary and Non-hereditary Cerebellar Ataxias in Latvia: Six Years of Experience at the National Reference Centre (ERN-RND Affiliated Partner)

Cerebellar ataxias are rare but disabling disorders, with marked regional differences in genetic subtypes. Data from Eastern Europe, especially the Baltic region, remain scarce. To describe the aetiological spectrum and diagnostic challenges of cerebellar ataxia in Latvia over a...

Extensive Cochlear Otosclerosis: CT-MRI Correlation and the Diagnostic Value of Contrast Enhancement

Otosclerosis is a chronic disorder of the otic capsule. It is characterized by abnormal bone remodeling, which may extend beyond the fenestral region and involve the cochlea and other structures of the bony labyrinth. There are two main types of otosclerosis—retrofenestral (cochl...

Gender-Based Discrimination and Its Associations with Mental Wellbeing, Self-Efficacy and Career Choice Among Medical Students in Latvia: A Cross-Sectional Study

Gender-based discrimination in medical education remains a critical yet overlooked issue that may adversely affect the mental health and professional development of future physicians. This study investigated the prevalence of such experiences and their association with mental wel...

Effects of Evolocumab on Mortality Outcomes in Patients Without Previous Myocardial Infarction or Stroke: A Prespecified Analysis of the VESALIUS-CV Randomized Clinical Trial

BACKGROUND: Evolocumab, a PCSK9 (proprotein convertase subtilisin–kexin type 9) inhibitor, significantly reduced the risk of cardiovascular events in patients without previous myocardial infarction or stroke in the VESALIUS-CV trial (Effect of Evolocumab in Patients at High Cardi...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Clinical and Immunological Associations of Plasma Platelet-Activating Factor in Chronic Spontaneous Urticaria

Background/Objectives: Chronic spontaneous urticaria (CSU) is a heterogeneous immune-mediated condition involving multiple inflammatory pathways. The clinical utility of platelet-activating factor (PAF) as a biomarker in CSU remains insufficiently defined. This study aimed to eva...