Pasteur Institute of Iran

Bifidobacterium longum prevent the progression of colon cancer via inhibiting metastasis and angiogenesis

Colorectal cancer (CRC) is one of the most common reasons for cancer-related death, and both angiogenesis and metastasis have established roles in CRC progression. Recent findings suggest that probiotics, like Bifidobacterium longum, are capable of suppressing anti-cancer activit...

α-Santonin from a marine sponge exhibits anticancer activity and mechanistic effects in colorectal cancer

Colorectal cancer (CRC) requires new therapeutic agents with minimal systemic toxicity. Marine-derived natural products represent a promising source of drug candidates because of their unique bioactivity. This study evaluated the anti-tumor potential and possible molecular mechan...

Expression patterns of miR-429/FN1 and miR-592/TOP2A in breast cancer: Clinicopathological correlations and diagnostic value

Breast cancer remains the most common cancer and a leading cause of cancer-related mortality among women worldwide. Identifying reliable biomarkers is essential for improving disease diagnosis and outcomes. This study aimed to evaluate the expression levels of miR-429 and miR-592...

Molecular correlates of elevated terbinafine and fluconazole MICs in Trichophyton mentagrophytes complex isolates

Abstract The Trichophyton mentagrophytes complex is a major etiological group in dermatophytosis, within which Trichophyton indotineae has emerged as an important cause of recalcitrant infection, with elevated minimum inhibitory concentrations (MICs) to first-line antifungal agen...

Context dependent roles of MicroRNA-377 in cancer from epigenetic silencing to therapeutic reactivation

MicroRNA-377 (miR-377) is a predominantly tumor-suppressive microRNA with context-dependent functions in cancer. Located within the imprinted DLK1-DIO3 region on chromosome 14q32, miR-377 regulates proliferation, apoptosis, invasion, metastasis, and treatment response, and its dy...

Epidemiology and antimicrobial resistance patterns of bloodstream infection pathogens in northern Iran

Bloodstream infection (BSIs) is life-threatening conditions associated with increasing antimicrobial resistance (AMR), particularly in low- and middle-income countries. Local surveillance data are essential to guide empirical therapy and antimicrobial stewardship. This study aime...

Trends (2014–2023), forecasting (2024–2026), and risk factors of drug-resistant tuberculosis in Iran: a negative binomial time-series generalized linear model

Drug-resistant tuberculosis (DR-TB) remains a major challenge for achieving the End TB Strategy. This study aimed to examine temporal trends of DR-TB in Iran, identify demographic and clinical risk factors, and forecast future incidence to support public health planning. A time s...

Synthesis and Analysis of Biochemical and Pharmaceutical Properties of Polysialylated Recombinant Streptokinase Enzyme

ABSTRACT Streptokinase (SK) is an enzyme drug and is used in medicine for dissolving clots in conditions such as heart attacks, lung artery emboli, vein thrombosis, and occlusions of arteries. Despite the impressive use of SK, its immunogenicity and short half‐life are major chal...