Institution
Pasteur Hellenic Institute
Recent research
- Health & MedicineOpen access
OBJECTIVES: To investigate the longitudinal clinical relevance of acetylcholine receptor (AChR) blocking antibodies in myasthenia gravis (MG). METHODS: We prospectively studied 47 AChR-positive MG patients with 121 serial antibody measurements over a mean follow-up of 2.8 years....
- BiologyOpen access
Natural products remain indispensable scaffolds in antiviral drug discovery, particularly against high-burden viral pathogens. In this study, two major sesquiterpene lactones, dehydrocostus lactone (1) and costunolide (2), were isolated from Laurus nobilis L. leaves and evaluated...
- Health & MedicineOpen access
Abstract The lack of an effective vaccine remains a critical barrier to controlling visceral leishmaniasis (VL), a lethal parasitic disease with expanding global incidence. Here, we evaluate extracellular vesicles (EVs) released by stationary-phase Leishmania infantum promastigot...
- BiologyOpen access
Abstract Orphan genes - genes lacking detectable homologs outside a species - are widespread in microbial genomes and are thought to contribute to their adaptation and molecular innovation. However, not all predicted orphan genes may represent novel functional coding sequences. F...
- Climate & EnvironmentOpen access
Carboxyl-modified polystyrene microplastics (cPS-MPs) may accumulate in the liver and interfere with cellular metabolism; however, their effects may differ substantially between cancerous and non-cancerous hepatocytes. In this study, we compared the responses of HUH-7 hepatocellu...
- Biology
Natural products represent an important source of bioactive compounds; however, their complexity often challenges conventional discovery approaches. In this study, an ethyl acetate extract of Artemisia arborescens (Vaill.) L. was investigated prior to any isolation using an integ...