Pasqual Maragall Foundation

Federated EGA in the European and Global Human Data Ecosystem

This Federated EGA in the European and Global Human Data Ecosystem white paper sets out our vision for the future role of Federated EGA (FEGA) in supporting secure, responsible and FAIR reuse of controlled-access human data. It describes how FEGA has developed into an operational...

Cognitive vergence and pupil response during oddball task are associated with Alzheimer´s disease cerebrospinal fluid neurodegenerative biomarkers

Alzheimer’s disease (AD) can be diagnosed using cerebrospinal fluid (CSF) biomarkers reflecting amyloid and tau pathology. However, they provide no information about functional network status. We aimed to determine whether CSF biomarkers (Aβ42, p-Tau, t-Tau, and Aβ42/p-Tau ratio)...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Cognitive vergence and pupillary responses as functional oculomotor signatures to differentiate AT(N) biological profiles in older adults with mild cognitive impairment

Abstract The locus coeruleus (LC), the earliest site of tau accumulation in Alzheimer’s disease, directly influences pupillary and vergence oculomotor systems. Whether task-evoked oculomotor dynamics can non-invasively differentiate AT(N) profiles, A+T+ (biological Alzheimer’s di...

Neurobiological correlates of longitudinal grey matter volume changes in preclinical Alzheimer’s disease

Background: Structural brain changes during the earliest asymptomatic stages of Alzheimer's disease (AD) remain poorly understood. Previous research in preclinical AD shows heterogeneous findings, reporting both subtle neuronal loss and paradoxical increases in grey matter (GM) v...

Converging pathomechanisms link SARS-CoV-2 infection with major neurodegenerative diseases

Neurological complications are among typical clinical manifestations, both during the acute phase of SARS-CoV-2 infection and long-term post-acute COVID-19 sequelae, i.e., Long COVID. A growing body of evidence connects SARS-CoV-2 infection to systemic inflammation, peripheral im...

Caregivers and technology: Digital content assessment on Alzheimer’s disease

Methods This study examined caregivers' preferences for digital content to support the care of individuals with dementia, particularly those with Alzheimer's disease (AD). An online survey was conducted with 147 caregivers affiliated with the Pasqual Maragall Foundation, assessin...