Park University

HIV and Antiretroviral Therapy Influence Tumor Microenvironment Architecture, Subclonal Evolution, and Immune Evasion Strategies in Diffuse Large B-Cell Lymphoma

The tumor immune microenvironment (TIME) and tumor heterogeneity shape prognosis and therapeutic response in Diffuse Large B-cell Lymphoma (DLBCL), but HIV-associated (HIV+) DLBCL remains poorly understood. To characterize the TIME and tumor-intrinsic features of DLBCL across a s...

Isolating Ligand Steric Effects on Metal Ion Reduction and Gold Nanoparticle Formation Pathways Using Au(I)–Phosphine Complexes

Abstract Steric effects are widely used to control molecular reactivity, yet their role in nanoparticle (NP) synthesis remains difficult to isolate and leverage because changes in ligand structure often alter both precursor electronic structure and resulting reduction thermodynam...

Field-Programmable Topological Torons in Chiral Nematic Liquid Crystals

Abstract Torons are three-dimensional double-twist solitons in chiral nematic liquid crystals (LCs), bounded by closed defect loops, that behave as particle-like entities while retaining a fully reconfigurable optical response. Here, it is shown that individual torons can be crea...

Data-Driven Methodologies For Pressure Probe Calibration: Integrating Symbolic Regression With Gaussian Process Regression

Abstract This study presents a unified data-driven calibration framework for five-hole pressure probes that combines symbolic regression with Gaussian process regression to improve accuracy, generalization, and interpretability across low-subsonic operating conditions (0.05 ≥ Ma...

Responsible Artificial Intelligence for Polypharmacy and Medication-Safety Risk in Older Adults: An Explainable FHIR-Based Clinical Decision-Support Framework

Medication-related harm in older adults is driven by the interaction of multimorbidity, age-related pharmacokinetic change, polypharmacy, potentially inappropriate medications, drug-drug interactions, fall-risk-increasing drugs and impaired renal function. Existing electronic pre...