Papworth Hospital NHS Foundation Trust

Knotless Suture Repair For Chronic Lateral Ankle Instability: A Systematic Review and Single-Arm Meta-Analysis

Introduction There is a need to assess the use of knotless sutures in cohorts with chronic ankle instability (CAI). Methods A literature search of Embase, Ovid MEDLINE, Cochrane Library and Scopus was conducted from each database’s inception to August 15, 2025. Eligible studies r...

Imaging-based biological age estimation predicts competing mortality risk in lung cancer screening

Abstract Lung cancer screening (LCS) participants have a high competing risk of non-lung cancer related death, which limits screening benefit. We hypothesized that imaging-based biological age can identify individuals at higher risk of non-lung cancer mortality. Low dose computed...

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

AIMS: In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker act...

Aortic Arch Surgery: Progress, Perspectives and Future Challenges

The aortic arch remains one of the most challenging areas in cardiac surgery, requiring a unique combination of surgical accuracy, physiological insight, multidisciplinary collaboration, and intraoperative decision-making [...]

How Does a Robotic Lung Resection Programme Evolve? Learning Curve and Conversion Analysis of the Versius CMR Surgical System

Background/Objectives: Robotic-assisted thoracic surgery continues to spread internationally for anatomical lung resection, yet evidence on learning curve dynamics and conversion behaviour remains limited beyond the da Vinci system. The published clinical experience on the Versiu...