Panyu District Central Hospital

Single-cell analysis reveals immunotherapy-induced epithelial state remodeling and identifies PLAUR as a prognostic biomarker in colorectal cancer

Immune checkpoint blockade has achieved durable responses in a subset of colorectal cancer (CRC) patients; however, the majority derive limited benefit. While previous studies have largely focused on immune cell dynamics, how tumor epithelial cells adapt to immune selection press...

Lateral internal sphincterotomy with skin grafting for chronic anal fissure: protocol of a multi-center randomized controlled trial

Abstract Background: Anal fissure, a prevalent anorectal disorder, is defined as a longitudinal tear in the anoderm distal to the dentate line.Chronicity develops in a substantial fraction of anal fissures despite initial conservative success, resulting in significant quality-of-...