Padjadjaran University

From fructose to steatosis, fructose-induced inflammation as a driver of hepatic injury and MAFLD progression: a systematic review of preclinical studies

Background Excessive dietary fructose has been implicated in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD), yet its specific role in driving hepatic inflammation remains incompletely defined. This systematic review aimed to synthesise recent pre...

Can artificial intelligence improve precision dosing? a systematic review of narrow therapeutic index drugs

Abstract Background Precision dosing of narrow therapeutic index drugs remains challenging because of substantial interindividual variability and the narrow margin between therapeutic efficacy and toxicity. Artificial intelligence (AI)–based approaches may improve individualized...

Cardiac monitoring and incidence of cardiotoxicity cardiomyopathy among breast cancer patients undergoing anthracycline regimen chemotherapy: insight from a single centre study

<title>Abstract</title> <bold>Background</bold> Anthracyclines remain a cornerstone of breast cancer therapy but carry a significant risk of cancer therapy-related cardiac dysfunction (CTRCD). This study evaluates the incidence of CTRCD in an Indonesian setting using the latest 2...

Pre-exposure to UV-B irradiation induces antioxidant enzymes and mitigates Fusarium acutatum stress in shallot ( Allium cepa L.)

Shallot (Allium cepa var. aggregatum) productivity is often limited by fungal diseases, particularly twisted disease caused by Fusarium acutatum. This study evaluated the effects of UV-B pre-exposure (150 min) on enhancing plant resistance under greenhouse conditions using four t...

Planning of potential mangrowe planting and tourism areas in Pangandaran Regency, West Java, Indonesia

This study aims to identify and plan potential areas for mangrove ecosystem planting (rehabilitation/restoration) as well as to identify and design potential areas for the development of sustainable mangrove ecotourism in Pangandaran Regency, West Java. This study focuses on six...

Validity of Using Artificial Intelligence to Predict Skeletal Maturation in Orthodontic Treatment: A Systematic Review and Meta-analysis

Abstract This systematic review aimed to evaluate the performance and clinical validation of artificial intelligence (AI) and rule-based methods for skeletal maturation assessment using cervical vertebral maturation (CVM) and hand–wrist radiography. The review was conducted in ac...

DETERMINATION OF POTENTIAL LOCATIONS FOR SETTLEMENT DEVELOPMENT BASED ON LAND CARRYING CAPACITY USING CELLULAR AUTOMATA (Case Study: Karangnunggal Subdistrict)

<ns5:p>Abstract Background Karangnunggal has been designated as the prospective capital of the Proposed New Autonomous Region of South Tasikmalaya Regency, a status expected to accelerate population growth and settlement land demand in an area that remains prone to landslides and...

Systematic mapping of artificial intelligence and big data architectures for antidiabetic drug discovery from traditional medical systems

Abstract Background Ethnomedical knowledge has contributed to the discovery and development of several contemporary antidiabetic agents. However, the extensive global diversity of medicinal plants, phytochemicals, and traditional therapeutic systems creates a substantial challeng...

Task-oriented circuit training to improve adaptive walking and cognitive-motor function after stroke: a clinical review

Abstract Background The evaluation of ambulation recovery after stroke commonly involves the use of linear outcomes such as walking speed and endurance. Task-oriented circuit training (TOCT) is commonly used in stroke rehabilitation to improve walking performance, but most existi...

Older adults’ participation and experiences in design thinking for AI-driven assistive technology: a scoping review

Abstract Background Population ageing and the rapid integration of artificial intelligence (AI) into assistive technologies have created a need to engage older adults as active partners in technology design. AI-driven assistive technologies are frequently developed with limited o...

Comparing fathers’ and mothers’ stunting knowledge and children’s oral health–related quality of life among stunted children

Abstract Background Stunting is linked to negative oral health outcomes and can diminish children’s oral health–related quality of life (OHRQoL). Parental roles and perceptions, particularly differences between fathers and mothers, may influence how oral health impacts are recogn...

Oral Microbiome Resilience: From Ecological Stability to Precision Oral Healthcare

Introduction: The concept of oral microbiome resilience has emerged as a new paradigm that emphasizes the ability of the oral microbial ecosystem to maintain ecological stability and recover from environmental disturbances. This concept provides a broader perspective than dysbios...

Exploring the in-vitro evaluation of folic acid-modified gadolinium nanoparticles in HEK-293, HeLa, and KB cancer cells for targeted-MR-imaging agent candidate

Abstract Folic acid (FA)-modified gadolinium nanoparticles are promising candidates for magnetic resonance imaging (MRI) contrast agents due to their high cancer specificity. Therefore, this study aims to modify nanoparticles with polyethylene glycol (PEG)-FA to enhance their bio...

Unravelling the genomic potential of sponge-associated Streptomyces sp. BLC 17–3 from Indonesia for mannooligosaccharide production

This research aims to show the promising capacity of Streptomyces sp. BLC 17–3 to produce high β-mannanase enzymes and generate mannooligosaccharide (MOS) such as mannobiose, mannotriose, mannotetraose and mannopentaose when exposed to mannan polymers. Streptomyces sp. BLC 17–3 w...

Development and validation of the IneRISE-Iman model: a spiritual care learning framework for undergraduate nursing students

Abstract Background Integrating spiritual care into undergraduate nursing curricula remains inconsistent, particularly in Muslim-majority contexts. Existing models are predominantly grounded in Western or secular frameworks and fail to adequately address the theological and cultu...

Urine-Derived Stem Cells: Challenges in Isolation, Biological Identity, and Therapeutic Potential in CKD-Associated Fibrosis

Urine-derived stem cells (UDSCs) have emerged as a promising cell source for regenerative medicine due to their non-invasive procurement, high proliferative capacity, and potential relevance to kidney-specific repair. Unlike conventional mesenchymal stem cells (MSCs) obtained fro...

ANALYSIS OF THE CARRYING CAPACITY AND SETTLEMENT CAPACITY IN ASSESSING THE READINESS OF KARANGNUNGGAL DISTRICT AS A CANDIDATE FOR THE CAPITAL OF SOUTH TASIKMALAYA REGENCY.

<ns5:p>Background The formation of the New Autonomous Region Candidate of South Tasikmalaya Regency has designated Karangnunggal District as a potential location for the regency capital. As the center of government and local activities, Karangnunggal faces significant challenges...

Bioactive Metabolites of Solanum tuberosum L. in Inflammation Modulation and Tissue Regeneration: A Scoping Review of Wound Healing Mechanisms

Background/Objectives: Persistent inflammation and impaired tissue regeneration delay mucosal and cutaneous wound healing. Potato (Solanum tuberosum L.) preparations contain bioactive metabolites with anti-inflammatory and regenerative potential, yet their wound-healing mechanism...

How the banks diversify and how it affects their performance

Purpose The purpose of this study is to be motivated to empirically investigate how banks evolve and adapt to a rapidly changing business environment by exercising diversification. The second motivation of this study is to look at how the heterogeneity of the banking system acros...