Pacific Research Institute

Rates of severe acute respiratory syndrome coronavirus 2 infection in a highly exposed South African blood donor cohort, 2022–2023

BACKGROUND AND OBJECTIVES: A cohort of South African repeat blood donors was established to leverage the repeated presentation of blood donors for longitudinal serological surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and reinfection inci...

Marine Benthic Cyanobacteria as Potential Bioresources for Rare Earth Element Management: Insights from Lanthanum Bioaccumulation and Strain-Specific Physiological Responses

Marine cyanobacteria represent a promising but underexplored bioresource for rare earth element (REE) management. This study investigated the effects of lanthanum (La, 10 mg L−1) on four cyanobacterial strains isolated from Black Sea periphyton: Desertifilum tharense AqMaPh-IBSS-...

Exploring genetic variability in FOXE1 through in silico approaches: new insights on UTR variants

<title>Abstract</title> The <italic>FOXE1</italic> gene is a transcription factor critical for thyroid development and function, and has been associated with thyroid disorders and other phenotypic traits like cancer and orofacial clefts. This study explores the genetic variabilit...

The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy

In individuals on effective antiretroviral therapy, integrated HIV proviruses persist within CD4 T cells, forming a viral reservoir that rebounds if treatment is stopped. Identifying and targeting these rare, infected cells is critical for advancing therapies, but methods to stud...