Pacific Biosciences (United States)

Hunting for microsatellite instability in long-read data with Owl

Abstract Microsatellite instability (MSI) is a key biomarker of mismatch repair deficiency and response to immunotherapy, yet most existing genomic detection methods are optimized for short-read sequencing and rely on small panels of homopolymer markers, limiting the ability to c...

A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance

Current lung cancer screening fails to identify many individuals at risk beyond heavy smokers, highlighting the need for additional predictive biomarkers. This study profiles circulating exosomal small non-coding RNAs (sncRNAs) in a prospective cohort of 202 smokers, including 68...