Oxford University Hospitals NHS Trust

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Evaluating the Uptake, Safety and Effectiveness of the Maternal RSV Vaccine (RSVpreF) Against Infant Bronchiolitis: Preliminary Real-World Evidence

BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization globally. On September 1, 2024, England introduced the bivalent RSVpreF vaccine for maternal immunization following trial evidence of safety and efficacy. However, real-world data on uptake...

Global trends in pleural infection mortality: a WHO-mortality database analysis

Background Current data suggest that the incidence of pleural infection is rising worldwide, however mortality data on global rates, trends and variations are lacking. Objectives To estimate pleural infection mortality rates across 24 Countries from 1994 to 2020 worldwide, using...

Adapting in-cell ELISA to investigate the localization of hepatitis C virus envelope glycoproteins

The development of hepatitis C virus (HCV) vaccines remains challenging due to extensive viral genetic diversity and the complex biology of the envelope glycoproteins E1 and E2, which are major targets of broadly neutralizing antibodies and are associated with spontaneous viral c...

Implementing prospective probabilistic scheduling of surgical cases to yield more predictable utilisations

We studied the impact of a prospective, probabilistic scheduling method to replace surgeon-led booking, balancing contradictory goals of maximizing theatre utilised time while minimizing risk of over-utilised time. Implemented in an NHS Scotland hospital, the study analyzed 2420...

Harmonizing M-protein analysis: an international, multi-center reproducibility study of mass spectrometry and evaluation of concordance to electrophoretic methods

Abstract Objectives Serum M-protein analysis is central to the assessment of monoclonal gammopathies. Quantitation and isotyping are commonly performed by SPE or CZE and IFE or IT, respectively. While these assays are widely used, they are characterized by limited sensitivity and...

Rethinking Muscle Wasting in Critical Illness: A Systematic Review and Meta-Analysis of Myofiber Size and Protein Turnover

OBJECTIVES: To identify biological findings underlying skeletal muscle dysfunction in adults with critical illness and meta-analyze myofiber cross-sectional area and protein turnover variables. DATA SOURCES: Six databases were electronically searched from inception to January 202...

Blended diets and considerations for enteral feeding

Patients requiring enteral tube feeding have typically relied on commercially prepared liquid enteral formula, but an increasing number of patients are choosing to blend their own foods at home (blended diet) or use a commercial thick formula containing real-food ingredients, wit...

Risk factors for scaphoid nonunion in acute fractures treated with cast immobilization

Aims: There is a lack of published evidence relating to the risk factors for nonunion seen in acute scaphoid fractures. We aimed to describe the risk factors for nonunion in adult patients (aged ≥ 16 years) treated with cast immobilization for acute scaphoid fractures. Methods: W...

ACPs – so much more than ‘doctors by another name’

Advanced clinical practitioners’ scope and value to teams and their specialties continue to be widely misunderstood

Icotrokinra (ICO), a Novel Targeted Oral Peptide, in Patients (Pts) with Psoriatic Disease: Exploratory Assessments from a Phase 2 Psoriasis (PsO) Study Informing a Phase 3 Clinical Program in Psoriatic Arthritis (PsA)

Objectives PsA affects ~20-30% of patients with PsO, causing articular inflammation and impaired quality of life. ICO, a novel targeted oral peptide that binds IL-23 receptor, showed greater clinical response rates vs placebo and a favorable safety profile in moderate-to-severe p...

Iron deficiency testing among people with incident heart failure in primary care

Background Given around 50% of people with heart failure have a degree of iron deficiency, guidelines recommend screening. It is uncertain to what extent this is done in primary care and whether testing is equitable. Aim To report the proportion of people with incident heart fail...