Oxford Research Group

Serological and transcriptomic response of African fruit bats to immune challenge with recombinant vaccines expressing Ebola or Nipah virus antigens

Abstract Bats are hosts to diverse zoonotic viruses which can cause high case fatality rates in humans. Since detecting viruses in bats is difficult, antibodies are often used for surveillance, though their significance remains unclear in the absence of in vivo immunological stud...

Steric control of signaling bias in the immunometabolic receptor GPR84

Abstract Biased signaling in G protein-coupled receptors offers therapeutic promise, yet rational design of biased ligands remains challenging due to limited mechanistic understanding. Here, we report a molecular basis for controlling signaling bias at the immunometabolic recepto...

Delivery of multiple PspA fragments by CyaA toxoid induces broad protection against Streptococcus pneumoniae

Abstract Streptococcus pneumoniae is a leading cause of lower respiratory tract (LRT) infections and invasive pneumococcal diseases (IPD). Conjugate vaccines are effective against IPD and nasal colonization but offer coverage limited to serotypes included in the formulations. Pne...

Evolution of South Asian mountain biota: dispersal, fine-scale biogeography, phylogenetics and systematics of Nannenini jumping spiders

The northward drift of the Indian subcontinent and its biotic exchanges with adjacent landmasses have shaped biodiversity in South Asia. We investigate biogeographic patterns and evolutionary relationships within a clade of spiders endemic to South Asia, focusing on two newly ide...