Oxford Health NHS Foundation Trust

Genetic evidence for the psychosis continuum: polygenic score analysis

Background The psychosis continuum conceptualises psychotic phenomena as existing on a spectrum from subclinical experiences to psychotic disorders. Despite epidemiological and clinical evidence in support of this model, few studies have examined polygenic liability across the se...

Impact of staff training on body temperature measurements during cancer treatment: a single-site quality improvement project

Background: Neutropenic sepsis is a serious complication of cancer therapy, and can often be detected by the presence of abnormal body temperature, typically fever. Aims: This research aimed to improve home temperature measurement in a cancer triage unit following a previous audi...

Sociodemographic, Criminological and Clinical Determinants in Suicide After Release From Prison: A 23‐Year National Cohort Study

ABSTRACT Background Suicide risk is elevated after prison release, but population‐level evidence on temporal risk patterns and associated factors remains limited. We aimed to describe characteristics of individuals who die by suicide after release from Norwegian prisons, compare...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials

Abstract Objective To compare the effect of specific antidepressants with placebo on heart rate corrected QT interval (QTc) during the first eight weeks of treatment for major depressive disorder in adults, and to investigate whether antidepressant use is associated with early ma...

Treatment interventions for longstanding and severe eating disorders: an updated systematic review and narrative synthesis

To update the evidence on treatment outcomes for adults with longstanding and severe eating disorders (ED) by reviewing quantitative studies published since 2019 and identifying priorities for future research. Systematic searches were conducted in June 2024 and updated in April 2...

Identifying Autism in Women Diagnosed with Borderline Personality Disorder: Clinician and Lived Experience Perspectives

Background: Growing numbers of people with a borderline personality disorder (BPD) diagnosis are querying whether they have undiagnosed autism. Previous qualitative research has not focused on identifying barriers and facilitators to this diagnostic journey, has not explored the...

“It All Exists Within Me”: A Qualitative Study Exploring Mental Health Service Experiences in Adults With Comorbid Eating Disorders and Emotionally Unstable Personality Disorder

ABSTRACT Objective Comorbidity between Eating Disorders (ED) and Emotionally Unstable Personality Disorder (EUPD) is high. This comorbidity is also linked with worse outcomes for traditional evidence‐based treatments. We aimed to improve mental health service experience for adult...

Myalgic encephalomyelitis/chronic fatigue syndrome and overlapping post-acute infection syndromes: international expert consensus framework for diagnostic standardization

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) lacks validated objective diagnostic criteria, leading to delayed diagnosis and inconsistent management. We aimed to establish an international expert consensus framework integrating measurable, risk-stratified assessmen...

Recombinant shingles vaccination and the risk of cardiovascular events

Abstract The recombinant herpes zoster (shingles) vaccine may reduce risks of cardiovascular disease. However, existing studies have compared vaccine recipients with non-recipients and, thus, are susceptible to confounding. To mitigate these biases, we conducted a natural experim...

Rethinking Muscle Wasting in Critical Illness: A Systematic Review and Meta-Analysis of Myofiber Size and Protein Turnover

OBJECTIVES: To identify biological findings underlying skeletal muscle dysfunction in adults with critical illness and meta-analyze myofiber cross-sectional area and protein turnover variables. DATA SOURCES: Six databases were electronically searched from inception to January 202...