Oxford BioMedica (United Kingdom)

Evaluating the Uptake, Safety and Effectiveness of the Maternal RSV Vaccine (RSVpreF) Against Infant Bronchiolitis: Preliminary Real-World Evidence

BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization globally. On September 1, 2024, England introduced the bivalent RSVpreF vaccine for maternal immunization following trial evidence of safety and efficacy. However, real-world data on uptake...

Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert®MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries

Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organisation (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRD...

An engineered helper plasmid generates differential E4orf6 and L4-22/33K gene expression increasing AAV vector production

Helper plasmids that depend on native adenovirus gene expression have long been the standard for transient adeno-associated virus (AAV) production. Here, we demonstrate that engineering the required helper gene expression can greatly increase AAV production relative to the use of...