Institution
Oxford BioMedica (United Kingdom)
Recent research
- Health & MedicineOpen access
ABSTRACT Objective To evaluate the incremental diagnostic yield of sequencing in a large, well‐phenotyped international cohort of fetuses with prenatally diagnosed agenesis of the corpus callosum (ACC) and to identify associated genes and variants. Methods Retrospective multicent...
- Health & MedicineOpen access
The C-reactive protein-triglyceride glucose index (CTI) is a composite indicator that integrates systemic inflammation, lipid metabolism, and glucose metabolism. Previous studies have reported an association between CTI and incident hypertension, but evidence across different gly...
- Health & MedicineOpen access
Clonal haematopoiesis (CH) is driven by somatic mutations in haematopoietic stem cells that generate clonal populations detectable in peripheral blood and is present in 10-20% of individuals over the age of 65. Mutations in DNMT3A and TET2 are the most common drivers and have bee...
- Health & MedicineOpen access
Abstract Purpose Comparison of available treatment modalities for neovascular AMD-related submacular haemorrhage including robot-assisted subretinal drug delivery. Methods Single centre, long-term, retrospective analysis of patients treated for nAMD-related submacular haemorrhage...
- Biology
Longitudinal dynamics of gene expression and metabolomics in an aging population cohort
Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudinal whole-blood gene expression and metabolite levels in 335 females over 8 year...
- Health & MedicineOpen access
Substandard and falsified (SF) medicines are a neglected public health threat, with an estimated 7% of antimicrobials in low- and middle-income countries being SF. However, quantifying their clinical impact remains challenging. We developed a general framework for estimating popu...
- Health & MedicineOpen access
A mixed methods evaluation of pleural procedural experience and training in intensive care trainees
Abstract Background Pleural procedures are key skills for Intensive Care Unit (ICU) doctors but can be associated with serious complications. We aimed to explore ICU junior doctors’ training, experience, and confidence in performing pleural procedures. Methods The study was a pro...
- Health & MedicineOpen access
Recombinant shingles vaccination and the risk of cardiovascular events
Abstract The recombinant herpes zoster (shingles) vaccine may reduce risks of cardiovascular disease. However, existing studies have compared vaccine recipients with non-recipients and, thus, are susceptible to confounding. To mitigate these biases, we conducted a natural experim...
- Health & Medicine
BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization globally. On September 1, 2024, England introduced the bivalent RSVpreF vaccine for maternal immunization following trial evidence of safety and efficacy. However, real-world data on uptake...
- Health & MedicineOpen access
Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organisation (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRD...
- BiologyOpen access
Helper plasmids that depend on native adenovirus gene expression have long been the standard for transient adeno-associated virus (AAV) production. Here, we demonstrate that engineering the required helper gene expression can greatly increase AAV production relative to the use of...