Outcomes Research Consortium

Using machine learning and preoperative data to predict 30-day mortality after non-cardiac major surgeries in older patients

Postoperative mortality remains a critical concern, especially among older patients undergoing non-cardiac major surgeries. With over 300 million surgeries performed worldwide annually, a significant proportion involves elderly patients, making early and precise risk stratificati...

Real-world cardiovascular effects of liraglutide: transportability analysis of the LEADER trial

Abstract Appropriate use of recently approved type 2 diabetes treatments depends on external validity of landmark clinical trials (RCTs) in real-world populations that may differ from trial participants. This study transported effect estimates from the Liraglutide Effect and Acti...

The Heart of the Matter — Transforming Congenital Heart Disease Care through Patient-Reported Outcomes

Patients with congenital heart disease (CHD) face substantial challenges in managing their chronic illness. Common and often unmet needs include neurocognitive challenges, mental health conditions, multiorgan disease, school and work impairment, and financial constraints. To impr...

Prenatal Water Fluoride Exposure and Children’s Behavioral Problems

Importance Although fluoride exposure at high levels during the perinatal period has been associated with socioemotional problems among children, there is limited evidence regarding potential associations at lower levels of fluoride exposure, particularly in the US. Objective To...

Loneliness, not isolation, is the missing link between social connectedness and mental health among midlife to older U.S. adults

Objectives To investigate whether loneliness or social isolation serves as the main pathway connecting social connectedness dimensions to mental health outcomes among midlife to older adults.Methods We examined longitudinal data from 4,963 adults aged 40–65 at baseline in the U.S...

Comparison of Machine Learning-Based Reporting with Surgeon Reporting of Postoperative Complication in Cardiothoracic Morbidity and Mortality Conferences

BACKGROUND: Traditional morbidity and mortality (M&M) conferences incompletely capture postoperative complications, potentially limiting quality improvement efforts. We developed and validated the Automated Surveillance of Postoperative Infectious and Non-Infectious Complications...

A pilot study of circulating DPP3 and renin to identify high-risk phenotypes and mortality in septic shock

Sepsis and septic shock are life-threatening conditions associated with high mortality and limited treatment options. Rapid identification of patients at risk for worse outcomes and/or targeted therapeutics are needed. Elevated levels of renin and dipeptidyl peptidase 3 (DPP3) in...

Perceptions of surrogate decision-makers of cardiac arrest patients on engaging in research during high emotional distress

The perception that individuals in crisis experience undue psychological burden by participation in research is a barrier to including surrogate decision-makers to critically ill patients in research studies. Importantly, perceptions from those who have engaged as surrogates are...

Empiric MRSA Coverage for Children with Osteoarticular Infections: 2015 to 2024

BACKGROUND AND OBJECTIVES Staphylococcus aureus is the most common causative pathogen for children with acute hematogenous osteomyelitis (AHO) and acute bacterial arthritis (ABA). National guidelines recommend empiric coverage for methicillin-resistant S. aureus (MRSA) at hospita...