Oulu University Hospital

Bariatric Surgery and Risk of Obesity-Related Cancer by Age and Sex

Importance Obesity is associated with elevated risks for multiple cancers. How bariatric surgery influences these risks across age and sex is insufficiently understood. Objective To evaluate the association between bariatric surgery and obesity-related cancer (breast, endometrial...

Identification and operative vs. conservative vs. no treatment trial of breastfeeding-impeding lingual frenulum in newborn infants (LINNE): protocol for a randomized controlled trial (RCT) embedded in a prospective observational cohort study in Northern Finland

The lingual frenulum is an anatomical structure of the mouth. If it restricts the movement of the tongue, it is called a tongue-tie. Existing evidence has linked tongue-tie to breastfeeding difficulties. With growing emphasis on successful breastfeeding, the number of surgical in...

Preoperative serum interleukin-6 and severe postoperative complications after colorectal cancer resection

Abstract Purpose To evaluate whether preoperative serum interleukin-6 (IL-6) is associated with severe postoperative complications after colorectal cancer resection. Methods This retrospective analysis included 474 patients undergoing curative-intent colorectal cancer resection a...

Age-based prognosis in oral tongue squamous cell carcinoma patients: A systematic review and meta-analysis

Abstract Background The prognostic significance of younger age in oral tongue squamous cell carcinoma (OTSCC) remains uncertain because age definitions, treatment strategies, outcome definitions, and adjustment methods vary substantially across studies. Objective To evaluate the...

Beyond Enabling Perspectives: How Organizational Conditions Shape Intertwined Forms of Professional Agency in Health and Social Care

Abstract The need to deepen our understanding of how organizational conditions shape the enactment of professional agency in the context of rapidly changing health and social care organizations is growing. Professional agency is understood in this study as a temporally embedded,...

Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk

Prospective evidence linking early-life microbiome development and host genetics with type 1 diabetes (T1D) risk is limited. Here, we describe how gut microbiome maturation and host genetics influence T1D risk in the TEDDY study. We analysed 12,151 longitudinal metagenomes and ho...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1

This is the first report of neuropathology in biallelic RFC1 expansion-associated Parkinson's disease (PD). It shows a synucleinopathy of intraneuronal Lewy bodies consistent with the clinical PD diagnosis while neuropathological CANVAS (Cerebellar Ataxia with Neuropathy and bila...

Menopausal status at the age of 46: Its association with depressive and anxiety symptoms and morbidity in women—A northern Finland birth cohort 1966 study

INTRODUCTION: The incidence of several morbidities increases during the menopausal transition. However, studies of the association between early-onset menopause and psychiatric symptoms and morbidity are scarce. We aimed to investigate how climacteric status at age 46 was associa...

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

Automated tooth number recognition from smartphone intraoral photographs using Mask R-CNN: internal and external validation study

Tooth numbering plays a significant role in dental care, providing accurate record keeping, diagnosis, and treatment of dental issues. The aim of this study was to evaluate the Mask Region-based Convolutional Neural Network (Mask R-CNN) model for tooth number detection, classific...

Students’ educational expectations: the role of school burnout and parental involvement

Adolescents’ educational expectations shape their futures. School burnout has been identified as affecting these expectations; however, research remains limited. Therefore, this study investigated the associations between school burnout (exhaustion and cynicism) and students’ edu...

The impact of patient-facing digital health interventions on patient safety outcomes: a meta-analysis of meta-analyses

Abstract Patient safety is a critical concern in healthcare, with preventable adverse events contributing significantly to morbidity and mortality. Digital health interventions (DHIs) are increasingly integrated into healthcare systems to improve patient safety outcomes. However,...

Translation, cultural adaptation and psychometric validation of the Shoulder Pain and Disability Index into Finnish

Shoulder pain is a leading cause of disability, often resulting in functional limitations and reduced quality of life. Valid, culturally adapted patient-reported outcome measures (PROMs) are essential for assessing symptoms and treatment outcomes across populations. The Shoulder...

Factors associated with a positive vaccination decision as described by vaccine-hesitant parents of pre-school-age children

Abstract Background Relatively few parents refuse all vaccinations for their children, but more and more have doubts and concerns about vaccination, even if their children have been vaccinated according to a vaccination program. This study identifies factors associated with a pos...

Applicability of Online Course for Teaching Diagnostic Criteria for Temporomandibular Disorders ( DC / TMD ) Axis I in Undergraduate Dental Education–Interexaminer Reliability Between Students and Teachers in a Student Exercise

ABSTRACT Introduction Temporomandibular disorders (TMDs) are common conditions affecting the masticatory system, causing pain and dysfunction. The DC/TMD Axis I protocol is increasingly included in undergraduate dental curricula. Aim To evaluate the applicability of a DC/TMD Axis...

Prevalence of Lumbar MRI Changes Associated with Nerve Root Compression Among Middle-aged People - A Northern Finland Birth Cohort 1966 Study

Study design. A cross-sectional study. Objective. To evaluate the prevalence of lumbar MRI changes associated with nerve root compression in a large, unselected middle-aged population. Summary of Background Data. While degenerative spinal changes are frequently observed in imagin...

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...

Complications and outcomes after operative treatment of low-energy pelvic ring and acetabular fractures

BACKGROUND: Fragility fracture of the pelvis (FFP) with a low-energy mechanism of injury is relatively common among the growing geriatric population. The incidence of postoperative complications after surgically treated FFP is not well documented. The aim of this study was to rep...