Ottawa Institute of Systems Biology

Syncytiotrophoblast differentiation defects drive ER stress and reprogram placental PSG1 glycosylation in preeclampsia

Abstract During pregnancy, placenta-derived proteins such as pregnancy-specific glycoprotein 1 (PSG1) enter the maternal circulation, providing a window into placental health and enabling liquid biopsy strategies for monitoring pregnancy disorders. PSG1, a highly glycosylated pro...

Gene body architecture predicts isoform diversity across eukaryotic genomes

Alternative splicing generates transcript and isoform diversity, but the gene-level features that distinguish isoform-rich genes from simpler genes remain incompletely defined. We examined whether structural, regulatory, sequence-derived, and functional features jointly explain i...