Ottawa Hospital Research Institute

Recent progress in emerging therapeutics and evaluation of oculopharyngeal muscular dystrophy

PURPOSE OF REVIEW: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset, genetic, neuromuscular disorder causing progressive ptosis, dysphagia and proximal muscle weakness. This review highlights emerging therapeutic strategies and recent advances in understanding the clinic...

Stellate ganglion block for posttraumatic stress disorder in Canadian Armed Forces Veterans and Royal Canadian Mounted Police: A case series

Introduction: Current treatments for posttraumatic stress disorder (PTSD) have shortcomings and less success in military Veterans. A significant challenge for recovery from PTSD is overcoming persistent and often intractable sympathetic hyper-arousal. This treatment gap has promp...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...