Ottawa Hospital Research Institute

Modernizing Canada’s Regulations for Clinical Trials in Medical Emergencies

Keywords: clinical trials; emergency; stroke• Health Canada recently announced the publication of proposed Clinical Trial Regulations, with specific sections addressing consent practices for clinical trials in medical emergencies.• These regulations aim to simplify existing guide...

Housing-based support models for individuals experiencing homelessness, substance use and mental health needs: a rapid review

Abstract Background Individuals experiencing homelessness and substance use and mental health needs face high rates of mortality. Stable housing is a critical determinant of health, yet the evidence on existing housingbased support models and their effectiveness for improving beh...

Nasal Packing After Trans-Sphenoidal Surgery for Pituitary Tumor: A Pilot of a Randomized Controlled Trial.

BACKGROUND AND OBJECTIVES: The goal of the study was to determine the feasibility of a larger trial to evaluate whether nasal packing after routine endoscopic endonasal resection of pituitary tumor negatively affects sinonasal quality of life (QOL) in the postoperative period and...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

Clinical, biochemical and genetic spectra of carnosinemia: a systematic review of case reports and case series

Abstract Carnosinemia, also referred to as carnosinase 1 (CNDP1) deficiency, is an ultra-rare inborn error of metabolism characterized by impaired CNDP1 activity and carnosine degradation. The clinical significance and phenotypic spectrum of this condition remain poorly defined,...

Development and internal validation of an EHR machine learning model for clinical deterioration in ICU linked inpatients

Abstract Early warning scores for inpatient deterioration rely predominantly on contemporaneous vital signs and may not incorporate broader electronic health record (EHR) information. We developed and internally validated a multi-domain EHR machine-learning model using MIMIC-IV v...

From Awareness to Action: Co‐Designing Culturally Safe and Equitable Rehabilitation in Canada – Protocol for the Two‐Phase Ireach Qualitative Study

ABSTRACT Background Inequities in access, engagement, and outcomes persist across outpatient rehabilitation services in Canada, disproportionately affecting Indigenous Peoples, newcomers and refugees, gender‐ and sexually‐diverse individuals, and people with lower income. Althoug...

Sex & Gender Science: integrating the social with the biological

Abstract For decades, researchers have largely studied aspects of sex and gender separately; the former as a basic science and the latter as a social construct with real world consequences, including health inequities. In recent years, as our collective understanding of how the b...

Recent progress in emerging therapeutics and evaluation of oculopharyngeal muscular dystrophy

PURPOSE OF REVIEW: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset, genetic, neuromuscular disorder causing progressive ptosis, dysphagia and proximal muscle weakness. This review highlights emerging therapeutic strategies and recent advances in understanding the clinic...

Stellate ganglion block for posttraumatic stress disorder in Canadian Armed Forces Veterans and Royal Canadian Mounted Police: A case series

Introduction: Current treatments for posttraumatic stress disorder (PTSD) have shortcomings and less success in military Veterans. A significant challenge for recovery from PTSD is overcoming persistent and often intractable sympathetic hyper-arousal. This treatment gap has promp...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...