Ottawa Hospital

Recent progress in emerging therapeutics and evaluation of oculopharyngeal muscular dystrophy

PURPOSE OF REVIEW: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset, genetic, neuromuscular disorder causing progressive ptosis, dysphagia and proximal muscle weakness. This review highlights emerging therapeutic strategies and recent advances in understanding the clinic...

Stellate ganglion block for posttraumatic stress disorder in Canadian Armed Forces Veterans and Royal Canadian Mounted Police: A case series

Introduction: Current treatments for posttraumatic stress disorder (PTSD) have shortcomings and less success in military Veterans. A significant challenge for recovery from PTSD is overcoming persistent and often intractable sympathetic hyper-arousal. This treatment gap has promp...

Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Localized Intermediate-Risk Prostate Cancer

Importance The treatment of prostate cancer with radiotherapy is evolving. How quickly radiotherapy can be delivered, and the relative risks and benefits of such a treatment, is of significant public interest. Objective To determine whether stereotactic body radiotherapy (SBRT) w...

Targeted transcriptome profiling of oral cavity squamous cell carcinoma and histologic grade-associated gene expression patterns

Aims To characterise gene expression differences between oral cavity squamous cell carcinoma (OSCC) and non-neoplastic oral mucosa using targeted transcriptome profiling and to evaluate gene expression patterns associated with tumour differentiation. Methods Formalin-fixed, paraf...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Efficacy, Tolerability, and Safety of Pitolisant for Residual Sleepiness in Obstructive Sleep Apnea Treated with CPAP: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

There is growing evidence on the use of pitolisant for the treatment of residual excessive daytime sleepiness (EDS) in adults with obstructive sleep apnea (OSA) treated with continuous positive airway pressure (CPAP). We conducted a systematic review and meta-analysis of randomiz...

Performance of the 2025 ASAS-Spartan Revised Classification Criteria for Axial Spondyloarthritis in a Canadian Multicenter Inception Cohort with Psoriasis, Uveitis, or Colitis Presenting with Undiagnosed Back Pain

Objectives To test the performance of the 2025 ASAS-SPARTAN Revised Classification Criteria for Axial Spondyloarthritis (axSpA)[1] in a multicenter inception cohort of patients with undiagnosed chronic back pain attending dermatology, ophthalmology, and gastroenterology clinics w...

Defining Difficult-to-Treat Rheumatoid Arthritis in Routine Care: Comparative Performance of Published Criteria and Description of Early and Late D2T-RA Phenotypes

Objectives Despite advances in treat-to-target strategies, a subset of rheumatoid arthritis (RA) patients remains refractory to therapy, described as difficult-to-treat RA (D2T-RA). The European Alliance of Associations for Rheumatology (EULAR) has proposed formal criteria for D2...

Reporting of justifications for withholding established effective interventions in randomised placebo-controlled trials: a systematic review

Randomised-controlled-trials (RCTs) are crucial for assessing the efficacy of new treatments. Some RCTs are placebo-controlled, which is uncontroversial when there is no established effective intervention or when a placebo is added to one. However, withholding an established effe...