Otsu Municipal Hospital

Longitudinal comparison of serum creatinine, estimated glomerular filtration rate, and blood urea nitrogen-to-creatinine ratio after initiation of palbociclib or abemaciclib: A single-center retrospective study

Introduction Abemaciclib inhibits renal tubular creatinine secretion and can increase serum creatinine without a true reduction in glomerular filtration rate. Direct real-world comparisons with palbociclib using routinely available laboratory markers are limited. Methods We condu...

Defining leadership competencies for rural community-based medicine: a Delphi study and field-based curriculum evaluation for undergraduate medical students

Abstract Background Leadership is essential in community-based medicine, yet inconsistently taught in Japan’s undergraduate medical curricula. This study aimed to: (1) identify essential community-based leadership competencies using a Delphi approach, (2) develop and pilot a stru...

Longitudinal Changes in the Blood Urea Nitrogen-to-Creatinine Ratio After Initiation of Abemaciclib: A Single-Center Retrospective Observational Study

Serum creatinine (Cr) elevation is frequently observed after the initiation of abemaciclib treatment. Because abemaciclib inhibits tubular creatinine secretion, Cr may increase without a true decline in glomerular filtration rate. In Japan, cystatin C is not routinely measured in...