Ospedale Vito Fazzi

A Multidisciplinary Care Pathway for Childhood Mouth Breathing: The Pediatric Allergist, ENT, and Orthodontic Perspective

Background: Mouth breathing (MB) in children is a functional alteration characterized by the substitution of nasal breathing with oral or mixed breathing. Persistent MB, particularly when occurring during sleep (nocturnal MB), may be associated with sleep fragmentation, neurobeha...

Illness Meaning-Making in an Oncology Support Group: A Longitudinal Lexical Correspondence Analysis of Group Discourse

Living with cancer involves an ongoing effort to make sense of experiences that disrupt identity, relationships, and future expectations. Meaning-making is embedded in interpersonal and healthcare contexts, including psychosocial support settings where illness experiences are sha...

Fracture Risk Stratification by REMS: A 5 Years Prospective Longitudinal Multicentre Study

Osteoporosis is a skeletal disorder characterized by low bone mass and deterioration of bone microarchitecture. Current predictive tools, mainly based on DXA-BMD, do not full capture all the factors contributing to bone deterioration. By combining information on bone quantity (T-...

Effect Modification of Rescue Stenting in ICAS-Related Middle Cerebral Artery Occlusion: The Role of Thrombectomy Failure, Stenosis Severity, and ASPECTS

Rescue stenting (RS) is increasingly used for intracranial artery stenosis-related large vessel occlusion (ICAS-LVO), but optimal patient selection remains uncertain. We investigated the baseline and procedural factors associated with receiving RS and whether they modified the as...

Insulin Resistance and Subclinical Myocardial Dysfunction in Type 2 Diabetes: A Cross-sectional Study

Introduction: Left atrial (LA) strain and left ventricular (LV) global longitudinal strain (GLS) on two-dimensional echocardiography in asymptomatic Type 2 diabetes mellitus (T2DM) patients might help recognise subclinical myocardial dysfunction in these patients. Since T2DM is a...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Real‐world outcomes of venetoclax plus hypomethylating agents in unfit acute myeloid leukaemia: Results of the GIMEMA AML2320 trial

Summary Venetoclax (VEN) plus hypomethylating agents (HMAs) represents the standard of care for newly diagnosed acute myeloid leukaemia (AML) patients unfit for intensive chemotherapy, but prospective real‐world observational data outside randomized clinical trials remain limited...

Sensing‐Integrated Patient‐Derived Tumorspheres Predict Chemotherapeutic Efficacy via Local Extracellular pH Dynamics

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies, due to late diagnosis, poor therapeutic response, and high inter‐ and intra‐patient heterogeneity. Metabolic alterations, particularly extracellular acidification, critically impair drug respons...

Multidisciplinary Delphi consensus-based recommendations on the use of image-guided radiotherapy for upper gastrointestinal tumours: an AIRO–AITRO–AIFM study

Abstract Objectives Upper gastrointestinal (GI) malignancies represent one of the most challenging scenarios for image-guided radiotherapy (IGRT). Despite technological advances, clinical practice remains heterogeneous among centres. This national, multidisciplinary Delphi consen...

Ultrasound-guided thermal ablation in patients affected by Graves’ disease: a systematic review and meta-analysis

Abstract Introduction Ultrasound-guided thermal ablation (U-GTA) techniques, including radiofrequency ablation (RFA) and microwave ablation (MWA), have recently been proposed as minimally invasive alternatives to surgery or radioiodine (RAI) therapy for patients with Graves’ dise...

Nonfermenting Gram-Negative Bacilli Other Than Pseudomonas and Acinetobacter Species in Pediatric Blood Cultures: A Multicenter European Analysis

BACKGROUND: Nonfermenting Gram-negative bacilli other than Pseudomonas and Acinetobacter species are increasingly recognized as opportunistic pathogens in pediatric populations, yet their epidemiology and antimicrobial resistance remain poorly defined. METHODS: We conducted a mul...