Ospedale Santa Maria Goretti

Video Head Impulse Test in the Diagnosis of Benign Paroxysmal Positional Vertigo: A Systematic Review of the Literature

Background: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder and is typically diagnosed based on characteristic positional nystagmus. Although video head impulse testing (vHIT) is increasingly used in vestibular disorders, its role in...

Effects of dupilumab on nasal mucociliary clearance in severe CRSwNP: evaluation of the saccharin test as an objective outcome measure

OBJECTIVE: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic, relapsing condition associated with a significant impairment in quality of life. Persistent inflammation contributes to dysfunction of mucociliary clearance. Dupilumab (IL-4Rα inhibitor) is a well-establis...

Increase in Healthcare-Associated Infections: Is COVID-19 Responsible? A Narrative Review

During the COVID-19 pandemic, healthcare-associated infections (HAIs) showed a significant increase, exacerbated by the prevalence of multidrug-resistant (MDR) organisms. Antibiotic overuse and infection control practices influenced HAI incidence rates, alongside the rising preva...

Transcriptomic profile and endothelial changes during differentiation syndrome in acute promyelocytic leukemia

Abstract Acute promyelocytic leukemia (APL) is curable with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), but differentiation syndrome (DS) remains a potentially life-threatening complication, with poorly understood pathogenesis. We investigated clinical, molecular a...