Ospedale Santa Maria della Misericordia di Udine

High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms, Clinical Evidence, and Persistent Misconceptions

High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedural settings, but it is often conceptually assimilated to non-invasive positive-pressure ventilation (NIPPV). This interpretation is physiologically misleading. HF...

Phenotype-based appropriateness of IGM-enriched polyclonal immunoglobulin use in critical illness: report of an expert consensus

Sepsis and septic shock result from a dysregulated host response to infection, encompassing both hyperinflammatory and immunosuppressed phenotypes. Although immunomodulatory adjunctive therapies have been extensively investigated over the past decades, none have demonstrated cons...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

Impact on blood cultures pre-analytical quality and positivity rate of a key performance indicators digital monitoring approach: a pre–post intervention study

Blood cultures (BCs) remain essential for diagnosing bloodstream infections, but their yield depends largely on pre-analytical phase quality. We evaluated the impact of an intervention guided by a digital platform for blood culture key performance indicators (KPIs) automated extr...

Professional portfolios as catalysts for competence development and career growth: a scoping review across professions

Purpose This scoping review aims to synthesize empirical evidence on outcomes associated with the use of professional portfolios (PPs) in workplace settings, addressing a gap in understanding their role as tools for professional and career development within human resource develo...

Clinical, Microbiological and Genomic Characterization of OXA-48-Producing Klebsiella pneumoniae ST395 Circulating in a Secondary-Care Hospital in North-Eastern Italy, 2024–2025

Background/Objectives: This study aimed to characterize the epidemiology, resistance, virulence determinants, and genomic relatedness of OXA-48-producing Klebsiella pneumoniae in a secondary-care hospital in north-eastern Italy, and to assess the in vitro activity of cefepime-bas...

Addressing the Limits of Emx2 Therapy of Glioblastoma Multiforme by Transgene Insulation and Epigenetic Pharmacological Intervention

Introduction/Objectives: Implicated in the regionalization of the anterior central nervous system (CNS) and the progression of pallial astrogliogenesis, the transcription factor gene EMX2 has been reported to be specifically silenced in several tumors, both non-neural and neural....

Expression of Active Apurinic Apyrimidinic Endodeoxyribonuclease 1 in Human Platelets

ABSTRACT The pivotal role of platelets (PLTs) in hemostasis, thrombosis, innate immunity, and tissue repair is sustained by mitochondria, whose dysfunctions can impair ATP generation and redox signaling, thus affecting optimal levels of PLTs' functionality. Maintenance of mtDNA i...

Cross-cultural adaptation and validation of the Localised Scleroderma Quality of Life Instrument (LoSQI): an international study

Juvenile localised scleroderma (jLS) is a rare disease which impacts negatively on health-related quality of life (HRQoL). We aimed to undertake the cross-cultural adaptation and validation of a novel disease-specific HRQoL measure, the Localised Scleroderma Quality of Life Instr...

Factors affecting the effectiveness of massive open online course in health professional education: an updated rapid review

A rapid review published in 2020 summarised factors and barriers influencing the effectiveness of MOOCs, to inform decisions regarding health professions education in the early days of the pandemic. No subsequent rapid reviews have updated this work to include evidence produced d...

A Modified Delphi consensus on early management of combined cardiovascular risk factors in adult patients with type 2 diabetes in Italy

BACKGROUND: Type 2 diabetes (T2D) is a complex chronic disease often associated with other metabolic conditions that increase the risk of cardiovascular (CV) disease and early mortality. Hence, early, integrated management of T2D may prevent long-term CV complications. METHODS: T...