Ospedale Santa Maria alle Scotte

A Multinuclear 1H and 31P NMR Approach for Quantification of Pneumococcal Cell-Wall Polysaccharide in Vaccine Development

Abstract Capsular polysaccharides are the principal constituents of S. pneumoniae capsules and major determinants of bacterial virulence. As key antigenic targets, they represent the foundation for pneumococcal vaccine development. Cell wall polysaccharides (CWPSs) commonly persi...