Ospedale San Luigi Gonzaga

Venous thromboembolism reporting in fusion-positive NSCLC treated with tyrosine kinase inhibitors: A systematic review of safety reporting and protocol-level provisions in phase I-IV clinical trials

BACKGROUND: Venous thromboembolism (VTE) is increasingly recognized as a clinically relevant complication in patients with fusion-positive non-small cell lung cancer (NSCLC). However, the completeness and consistency of thromboembolic safety reporting in clinical trials of tyrosi...

Haemoglobinopathies in Newborn Screening: Epidemiological Findings and Exploratory Analysis of HbA0 Distribution in a Population-Based Neonatal Cohort from Northern Italy

Haemoglobinopathies are an increasing health concern in Europe due to changing population demographics. In Italy, however, newborn screening (NBS) for haemoglobinopathies is not yet included in the national mandatory screening panel. The primary aim of this study was to estimate...

Osimertinib–Savolitinib in Advanced NSCLC after Progression during EGFR-TKI Therapy

BackgroundSavolitinib is an oral, potent, highly selective MET–tyrosine kinase inhibitor (TKI). Combination therapy with savolitinib and osimertinib, an epidermal growth factor receptor (EGFR)–TKI, has shown activity in patients with EGFR-mutated, advanced non–small-cell lung can...

Emerging therapeutic strategies and clinical trials in severe asthma management: current evidence and future directions

Introduction Biologic therapies have transformed the management of severe asthma, particularly in type 2-high disease, but important unmet needs remain. Incomplete responses, uncertainty in treatment positioning, and the lack of effective options for non-type 2 or mixed inflammat...

Interstitial Lung Abnormalities: A Multidisciplinary Narrative Review

Abstract Interstitial lung abnormalities (ILAs) is an umbrella term used to describe a spectrum of computed tomography (CT)-detected lung abnormalities that may reflect interstitial lung disease (ILD). Initially perceived as a niche topic—and often underreported in clinical pract...

Feasibility of Using Digital Clinical Records to Identify Factors Associated with Nursing-Sensitive Outcomes During Hospitalization: A Pilot Study

Background/Objectives: Nursing-sensitive outcomes are key indicators of nursing care quality and safety. Digitalization of clinical documentation enables prospective surveillance using routine data, but real-world evidence on integrated digital, clinical record-based approaches r...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

The paracrine Ephrin A4/BMP4 feed-forward loop sustains a tumor–CAF vicious cycle in osteosarcoma

Abstract Background Advanced osteosarcoma (OS) remains a clinical challenge due to its aggressive behavior and poor prognosis. Cancer-associated fibroblasts (CAFs) have been shown to contribute to tumor progression, but the tumor–CAF crosstalk in OS is still poorly defined. Eluci...