Ospedale San Giuseppe

A 5D dynamic bicellular in vitro model recapitulates the aetiopathogenic triad of systemic sclerosis: a preliminary proof-of-concept study

The present work aimed at modelling in vitro the interplay between immune complexes (ICs) containing scleroderma-specific antibodies, vasculopathy and skin fibrosis to reproduce the multifaceted etiopathogenesis of systemic sclerosis (SSc). Endothelial cells (ECs) were grown in a...

Horizon Scanning of Multiple Sclerosis Expenditure in Italy (2025–2029): Updated Insights from the Oracle Model

Multiple sclerosis (MS) is a chronic and progressively disabling neurological disease associated with a substantial clinical and socioeconomic burden. The introduction of an increasing number of new innovative therapies has further intensified concerns regarding the long-term sus...

Therapeutic potential of positive allosteric modulators of AMPA receptors in brain disorders

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA receptors) are ionotropic glutamate receptors that mediate fast excitatory neurotransmission in the central nervous system. By translating chemical signals into rapid electrical depolarization, AMPA receptors, t...

Spatial extension of parafoveal processing predicts reading speed gain during reading acceleration

Fast and efficient reading involves not only processing the currently fixated word but also simultaneous processing of the upcoming text. Although the role of extrafoveal processing in natural reading has been extensively documented, its contribution to reading acceleration benef...

Central neurocytomas: Decision-making process of postoperative treatment. Lesson learned

Central neurocytoma is a rare intraventricular tumor with favorable prognosis following gross total resection (GTR). However, the role of Ki67-MIB1 values in the postoperative decision making-process of treatment, as well as the indication for adjuvant radiotherapy, remain debate...

A rare case of abdominal actinomycosis mimicking ovarian cancer with presumed hepatic involvement and abdominal wall involvement

species. Because of its infiltrative growth, abscess formation, and fibrotic reaction, it may closely mimic malignant disease. We report the case of a 53-year-old woman presenting with abdominal pain and a palpable epigastric mass. Imaging showed a pelvic mass with abdominal wall...

Cortical dynamics in Angelman syndrome: novel insights from a preclinical mouse model

Angelman syndrome (AS) is a neurogenetic disorder caused by the loss of function in the maternally inherited UBE3A gene, leading to a spectrum of symptoms that include developmental delays, intellectual disability, and motor impairments. While genetic and molecular mechanisms of...

Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications

Placebo and nocebo effects on pain provide a model for investigating how cognitive and contextual factors modulate the physiological processes underlying nociception and its regulation. However, existing accounts remain fragmented and lack a unifying mechanistic framework linking...