Ospedale San Carlo

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Weight-loss and body-composition trajectories after bariatric surgery may follow different timelines

Weight stability is commonly used as a practical marker after bariatric surgery and may influence the timing of subsequent elective procedures. Recent longitudinal body-composition data show that changes in body weight, fat mass, fat-free mass, skeletal muscle mass, and phase ang...

Focused Ultrasound-Mediated Blood–Brain Barrier Opening for Enhanced Drug Delivery in Diffuse Gliomas: A Systematic Review

Background/Objectives: The blood–brain barrier (BBB) severely limits the intratumoral delivery of systemically administered therapeutics in diffuse gliomas, including glioblastoma (GBM), contributing to the persistently poor prognosis of these tumors. Focused ultrasound (FUS) com...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Phenotype-based appropriateness of IGM-enriched polyclonal immunoglobulin use in critical illness: report of an expert consensus

Sepsis and septic shock result from a dysregulated host response to infection, encompassing both hyperinflammatory and immunosuppressed phenotypes. Although immunomodulatory adjunctive therapies have been extensively investigated over the past decades, none have demonstrated cons...

Predicting the risk of dehydration and readmission among rectal cancer patients with ileostomy: a multicenter observational study

Abstract Dehydration is a frequent complication among rectal cancer patients after ileostomy, often resulting in hospital readmission. The Dehydration Readmission after Ileostomy Prediction (DRIP) score was used to identify patients at risk of dehydration-related readmission. The...

Increase in Healthcare-Associated Infections: Is COVID-19 Responsible? A Narrative Review

During the COVID-19 pandemic, healthcare-associated infections (HAIs) showed a significant increase, exacerbated by the prevalence of multidrug-resistant (MDR) organisms. Antibiotic overuse and infection control practices influenced HAI incidence rates, alongside the rising preva...

Severity of Reactions in Double-Blind Placebo-Controlled Food Challenges: New Insights From the EuroPrevall Outpatient Clinic Study

BACKGROUND AND OBJECTIVES: Oral food challenge, particularly double-blind placebo-controlled food challenge (DBPCFC), is the gold standard for diagnosis of food allergy, although safety concerns limit its widespread use. Objectives: To evaluate the severity of reactions during DB...

Discontinuous Peripheral Punctate Echogenic Foci in Thyroid Nodules: A New Sonographic Pattern Suggestive of Papillary Carcinoma

Background: Ultrasound risk stratification systems for thyroid nodules worldwide describe different types of echogenic foci, including punctate echogenic foci (microcalcifications), coarse internal calcifications, and peripheral (rim) calcifications (complete or incomplete), with...