Ospedale Regina Margherita

Long-term results of the modified Dunn procedure in slipped capital femoral epiphysis

Aims: In situ fixation for slipped capital femoral epiphysis (SCFE) prevents further displacement, but fails to correct the proximal femoral deformity, which may lead to femoroacetabular impingement (FAI) and early osteoarthritis (OA). The modified Dunn procedure (MDP) restores p...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

3D virtual reconstruction: usefulness in preoperative planning for oncologic renal surgery in children

Preoperative planning for complex pediatric renal masses can be challenging, especially when nephron-sparing surgery (NSS) is recommended. We report our experience using 3D virtual reconstruction (3DVR) and its impact on surgical decision making. Patients with complex renal masse...

Postpandemic Trends in Pediatric Respiratory Virus Hospitalizations: A Multicenter Study, 2019–2025

ABSTRACT Background The COVID‐19 pandemic profoundly altered the circulation of respiratory viruses in children, changing the epidemiology of acute lower respiratory tract infections. In the postpandemic period, respiratory pathogens showed marked temporal variability. The 2024–2...

Epidemiology, impact on oncologic treatments, and management of community-acquired respiratory virus (CARV) infections in pediatric onco-hematology patients: a survey among Italian pediatric oncology hematology centres (AIEOP)

Abstract A survey was conducted across Italian Pediatric Onco‑Hematology centres to assess epidemiology of community‑acquired respiratory virus (CARV) infections, chemotherapy management, Oseltamivir use and vaccination policies. Most reported infections were mild and managed out...

A survey on the institutional practices of the use of isavuconazole in onco-hematological children, on behalf of the Infectious Working Group of AIEOP

Isavuconazole is a broad-spectrum antifungal agent approved for the treatment of invasive fungal infections (IFIs) in adults and, recently, in pediatric patients aged 1 year and older. Use in the pediatric setting remains limited, but available data indicate generally favorable s...

Advancing cancer care for adolescents and young adults: the role of the European Network of Expertise

Adolescents and young adults (AYAs, aged 15-39 years at cancer diagnosis) are recognized as a distinct patient group with specific clinical and psychosocial needs requiring tailored care. This article presents the Network of Expertise (NoE) on AYAs with cancer developed through t...

The paracrine Ephrin A4/BMP4 feed-forward loop sustains a tumor–CAF vicious cycle in osteosarcoma

Abstract Background Advanced osteosarcoma (OS) remains a clinical challenge due to its aggressive behavior and poor prognosis. Cancer-associated fibroblasts (CAFs) have been shown to contribute to tumor progression, but the tumor–CAF crosstalk in OS is still poorly defined. Eluci...

Updating the Prevalence of H. pylori and Extensive Precancerous Lesions in the Stomach: Results of a Multicenter, Endoscopic Study

Background/Objectives: H. pylori is the main preventable risk factor for gastric cancer through the development of extensive precancerous lesions, namely mucosal atrophy and intestinal metaplasia. Methods: This multicenter, nationwide study enrolled consecutive patients who under...

HPV DNA negativity following AHCC or nonavalent vaccination or their combination in women with persistent HPV infection without HSIL

Persistent infection with high-risk human papillomavirus (HR-HPV) is a common clinical condition for which no validated systemic antiviral therapy is currently available, and in the absence of high-grade cervical lesions management is generally limited to surveillance. Active Hex...

Epstein–Barr Virus DNA Detection Without Detectable Expression of Selected Viral Transcripts in Pediatric Patients with Systemic Lupus Erythematosus

Background: Epstein–Barr virus (EBV) has long been linked to systemic lupus erythematosus (SLE), mainly through molecular mimicry, altered B-cell biology, defective antiviral immune surveillance and intermittent viral reactivation. However, the detection of EBV DNA in clinical sa...

When biological complexity demands more than better trial designs

The increasing complexity of precision medicine has highlighted the limitations of traditional randomized clinical trials (RCTs) when applied to highly stratified populations and biologically heterogeneous diseases. In this context, master protocols represent an evolution towards...

Vaccination in pediatric transplantation—General recommendations. A position paper by the European Reference Network TransplantChild

Infectious diseases remain a leading cause of morbidity and mortality among pediatric transplant recipients, despite significant advances in transplantation management. Vaccination is the most effective strategy to prevent infections; however, its efficacy is hindered in solid or...

Susceptibility haplotypes in non-cystic fibrosis newborns with elevated immunoreactive trypsinogen

Cystic fibrosis (CF) represents the most prevalent life-threatening autosomal recessive disorder in Europe, primarily affecting the respiratory tract, exocrine pancreatic function, and lipid metabolism. Immunoreactive trypsinogen (IRT) quantification constitutes the first-tier te...