Ospedale dei Pellegrini

CLDN18 as a novel junctional biomarker enhancing multi-gene classification of pancreatic cancer

Pancreatic adenocarcinoma (PAAD) remains one of the most lethal cancers, largely due to the lack of reliable diagnostic biomarkers. Through integrative transcriptomic and proteomic analyses, we evaluated a four-gene signature comprising CLDN18, CEACAM5, FUT3, and FUT6, capable of...