Osaka Women's and Children's Hospital

Orthodontic and surgical treatment patterns in hemifacial microsomia: a retrospective multi-institutional study in Japan

Hemifacial microsomia is a congenital craniofacial condition characterized by variable facial asymmetry and mandibular hypoplasia. Its management often requires long-term multidisciplinary care, including orthodontic and surgical treatment. However, multi-institutional data on tr...

Intratumoral Administration of Recombinant Murine Interleukin‐12 Prevents Tumor Progression and Bone Invasion

ABSTRACT Background Oral squamous cell carcinoma (OSCC) progression is accompanied by bone invasion. Therefore, maintaining oral function is necessary to regulate tumor progression. Also, interleukin-12 (IL-12), a well-known anti-tumor cytokine, can suppress osteoclast differenti...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...