Osaka University of Pharmaceutical Sciences

Development of YO-01027-Derived Signal Peptide Peptidase Inhibitors with Reduced γ-Secretase Inhibition

Abstract Signal peptide peptidase (SPP) is an endoplasmic-reticulum intramembrane aspartyl protease required for hepatitis C virus (HCV) core protein maturation, but many SPP inhibitors also inhibit γ-secretase. Here, we designed YO-01027-derived dibenzazepinone analogs to retain...

Drug-Dependent Disruption of Amyloid Nanofibril-Mediated Wrinkling in Supraparticle Assemblies

Supraparticles (SPs) are secondary particles formed through nanoparticle self-assembly with porous architectures and bioinspired structural features suitable for drug delivery applications. Although binder-mediated structural control influences SP assembly, how different loaded d...

A novel machine-learning model using nuclear features to predict upper tract urothelial carcinoma recurrence

Abstract Upper-tract urothelial carcinoma (UTUC) is rare, constitutes < 5% of urothelial cancers, and, given its insidious clinical presentation, is typically diagnosed at advanced stages; post-radical nephroureterectomy recurrence remains challenging. Postoperative management is...

Quality of Life and Physical Status Among Individuals with Alcohol Dependence Before, During, and After the COVID-19 Pandemic: A Repeated Cross-Sectional Study

We examined changes in psychological and physical status among individuals with alcohol dependence before, during, and after the COVID 19 pandemic, aiming to identify factors related to quality of life (QOL) and hepatic reserve. We conducted a retrospective repeated cross-section...

Endoscopic transsphenoidal surgery for a somatotroph pituitary neuroendocrine tumor associated with an infraoptic course of the anterior cerebral artery: A case report

Background: Identifying cerebrovascular anomalies before neurosurgical procedures is essential to avoid intraoperative complications. An infraoptic course of the anterior cerebral artery (IOA) is a rare variant in which the anterior cerebral artery (ACA) arises near the ophthalmi...

A multicenter phase II trial of ramucirumab plus irinotecan for early recurrence of gastric cancer during or after adjuvant chemotherapy with docetaxel plus S-1 therapy: the RAMIEL trial (OGSG1901)

Abstract Background There is currently no established chemotherapy regimen for early recurrence of pathological stage III gastric cancer (GC) following adjuvant chemotherapy with docetaxel plus S-1 (DS) after D2 gastrectomy. We aimed to evaluate the efficacy and safety of ramucir...

Integrated Analysis of HER2 Expression and ERBB2 Alterations in Bladder Cancer

ABSTRACT Human epidermal growth factor receptor 2 (HER2) has emerged as a potential therapeutic target in bladder cancer (BC), particularly with the advent of next‐generation antibody–drug conjugates (ADCs) like trastuzumab deruxtecan (T‐DXd). However, the complex relationship be...

Impact of baseline renal function on the clinical outcomes and safety of adjuvant nivolumab in high-risk urothelial carcinoma: a multicenter retrospective real-world study

Abstract Background Adjuvant nivolumab prolongs disease-free survival (DFS) in patients with urothelial carcinoma (UC) after radical surgery; however, evidence in those with reduced baseline renal function is limited. We investigated the impact of baseline creatinine clearance (C...

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

Development of a prognostic model for elderly patients with metastatic clear cell renal cell carcinoma treated with first-line immuno-oncology combination therapy.

BACKGROUND: In the era of immuno-oncology (IO) combination therapy, prognostic tools for elderly patients with metastatic clear cell renal cell carcinoma (ccRCC) are lacking. This study aimed to identify prognostic factors in elderly patients and evaluate a novel risk model using...

Effect modification by baseline lactate in the association between time to assigned mean arterial pressure target and outcomes in older patients with septic shock: a post hoc analysis of the OPTPRESS trial

Time to target mean arterial pressure (TTT-MAP) may capture the temporal dimension of circulatory recovery in septic shock; however, its prognostic relevance needs clarification. This study aimed to investigate the impact of baseline lactate on the TTT-MAP-clinical outcome associ...

Serum C4/C3 ratio at disease onset predicts end-stage renal disease in microscopic polyangiitis: the multicentre REVEAL cohort

We investigated whether serum complement C3 and C4 levels and the C4/C3 ratio at disease onset were associated with clinical features, renal involvement, and prognosis in microscopic polyangiitis (MPA). Patients were stratified into tertiles according to baseline C3 and C4 levels...

Epidemiology of macular dystrophy in Japan (2011–2020): a nationwide population-based study

Abstract Purpose To describe the characteristics and prevalence of macular dystrophy using a comprehensive national claims database in Japan. Study design Population-based retrospective study using a nationwide claims database. Methods Approximately 126 million individuals covere...

Structural insights into fosfomycin efflux by a streptococcal ABC transporter

ABSTRACT Gram-positive bacteria encode a broad array of ABC transporters that mediate substrate translocation across the cell membrane, with some contributing to their survival under environmental stresses such as antimicrobial exposure. While several of these transporters have b...

Development of an interprofessional education program for aspiration pneumonia care: an action research study

INTRODUCTION/AIM: Aspiration pneumonia has evolved, with demographics shifting to predominantly frail older adults. However, despite the high healthcare impact, there is no established guideline or curriculum for the education and training of healthcare professionals in managing...

Clinical Impact of Gleason Pattern 5 on Doublet Versus Triplet Therapy in Metastatic Hormone‐Sensitive Prostate Cancer

BACKGROUND: Upfront treatment intensification with androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor has become a standard approach for metastatic hormone-sensitive prostate cancer (mHSPC). However, prognosis remains poor for some patients despite sec...

Standardization of shotgun metagenomics parameters for pks-positive enterobacteria detection in human fecal samples: Receiver operating characteristic analysis using polymerase chain reaction as reference standard

Enterobacteria harboring the polyketide synthase ( pks ) island ( clbA – clbS ), which encodes colibactin ( pks⁺ enterobacteria), is a putative risk factor for colorectal cancer. Polymerase chain reaction (PCR) is the current standard for detection. Primer-independent shotgun met...