Osaka University Hospital

Diagnostic accuracy of 18F-PSMA-1007 PET/CT and bone scintigraphy for detecting bone metastases in prostate cancer

Abstract Objective The performance of 18 F-labeled prostate-specific membrane antigen ( 18 F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) and bone scintigraphy (BS) for detecting bone metastases in prostate cancer patients was compared. Materials and metho...

A multicenter phase II trial of ramucirumab plus irinotecan for early recurrence of gastric cancer during or after adjuvant chemotherapy with docetaxel plus S-1 therapy: the RAMIEL trial (OGSG1901)

Abstract Background There is currently no established chemotherapy regimen for early recurrence of pathological stage III gastric cancer (GC) following adjuvant chemotherapy with docetaxel plus S-1 (DS) after D2 gastrectomy. We aimed to evaluate the efficacy and safety of ramucir...

Effects of the Institutional Volume of Endovascular Treatment for Lower Extremity Artery Disease on Radiation Exposure

Purpose: The procedure time of endovascular treatment (EVT) for lower extremity artery disease (LEAD) may increase as its application expands to more complex lesions. Given this trend and the growing importance of radiation protection, this study investigated the association betw...

Effect modification by baseline lactate in the association between time to assigned mean arterial pressure target and outcomes in older patients with septic shock: a post hoc analysis of the OPTPRESS trial

Time to target mean arterial pressure (TTT-MAP) may capture the temporal dimension of circulatory recovery in septic shock; however, its prognostic relevance needs clarification. This study aimed to investigate the impact of baseline lactate on the TTT-MAP-clinical outcome associ...

Intratumoral Administration of Recombinant Murine Interleukin‐12 Prevents Tumor Progression and Bone Invasion

ABSTRACT Background Oral squamous cell carcinoma (OSCC) progression is accompanied by bone invasion. Therefore, maintaining oral function is necessary to regulate tumor progression. Also, interleukin-12 (IL-12), a well-known anti-tumor cytokine, can suppress osteoclast differenti...

Hip anteroposterior radiographic indices for effective osteoporosis screening in female patients undergoing total hip arthroplasty

Abstract Summary Osteoporosis in patients awaiting total hip arthroplasty remains undiagnosed. Although hip radiographic indices have been proposed for screening, they have not been compared. We compared the diagnostic accuracy of eight indices for osteoporosis. The canal–bone ra...

Distribution and Time Trends of Refractive Errors in Japanese Spectacle Wearers

Purpose: This study aimed to estimate the distribution and temporal trends of refractive errors among spectacle wearers in Japan using a nationwide database of optical chain stores. Methods: Data from 4,525,689 individuals (53.0% women and 47.0% men; age range, 6-35 years) who pu...

Clinical Impact of Gleason Pattern 5 on Doublet Versus Triplet Therapy in Metastatic Hormone‐Sensitive Prostate Cancer

BACKGROUND: Upfront treatment intensification with androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor has become a standard approach for metastatic hormone-sensitive prostate cancer (mHSPC). However, prognosis remains poor for some patients despite sec...