Osaka Research Institute of Industrial Science and Technology

Device-assisted calf-raise training combining high-speed and eccentric exercises improves gait speed in older adults

Abstract Plantar flexors are critical for mobility in older adults. Although movement velocity contributes to gait performance in addition to strength, few interventions target both plantar flexor strength and velocity. To address this gap, we developed a novel device to support...

Beyond Translation Initiation: Translational Elongation, Decoding Fidelity, and Ribosome Surveillance During Branched-Chain Amino Acid Deprivation, with a Focus on Mammalian Systems

In mammalian systems, translational responses to amino acid limitation are commonly framed as mechanistic target of rapamycin complex 1 (mTORC1) inhibition and activation of the general control nonderepressible 2 (GCN2)–eukaryotic initiation factor 2α (eIF2α) arm of the integrate...

Clinical relevance of serum full-length glypican-3 in unresectable hepatocellular carcinoma treated with atezolizumab and bevacizumab

Abstract Biomarkers that can predict patient survival and the therapeutic response to atezolizumab and bevacizumab (Atezo/Bev) as first-line chemotherapy for unresectable hepatocellular carcinoma (HCC) have yet to be identified. We aimed to determine whether the serum full-length...

Molecular dynamics study on anisotropic water cluster formation in polyethylene: A fundamental perspective on water tree initiation

The microscopic mechanisms of water tree inception in polymeric insulating materials remain a critical challenge for high-voltage engineering. In this study, molecular dynamics simulations were employed to investigate the structural and kinetic responses of water nanoclusters in...