Osaka Gakuin University

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Post-traumatic stress disorder (PTSD) is a mental health disorder triggered by exposure to a traumatic event, which manifests with anguish, intrusive memories, and negative mood changes. So far, there is no efficient treatment for PTSD other than symptomatic palliative care. Howe...

Shotgun metagenomic sequencing of serum extracellular vesicle-derived DNA enables microbial profiling in urothelial carcinoma

Shotgun metagenomic sequencing provides more detailed microbial information than 16 S rRNA sequencing but requires higher cost and larger sample volumes. We evaluated whether shotgun metagenomic sequencing could detect bacterial DNA in serum extracellular vesicles. Serum samples...

Manufacturing Paradigm III—From Conception to the Academic Frontier

The theory of the “three paradigms of manufacturing development” is derived from a systematic analysis of the evolution of manufacturing precision and controllable feature size. It posits that Manufacturing Paradigm III is grounded in quantum theory as its new theoretical foundat...

Diboron‐Embedded Heteroacenes With Systematically Varied Central π‐Skeletons and Fusion Modes

ABSTRACT Diboron‐embedded heteroacenes with systematically varied central π‐skeletons and fusion modes were synthesized via one‐pot cyclative borylation using benzene, thieno[3,2‐ b ]thiophene, or dithieno[3,2‐ b :2′,3′‐ d ]thiophene cores, affording six derivatives with C 2h or...

Cord Blood‐Derived Fibroblast Activation Protein‐Targeted Chimeric Antigen Receptor Natural Killer Cells Persist in Vivo

ABSTRACT Cancer‐associated fibroblasts (CAFs) have been recognized as key contributors to tumor progression. Chimeric antigen receptor (CAR) T‐cell therapy targeting fibroblast activation protein (FAP), a marker of CAFs, has gained attention and is being evaluated in both preclin...

Control of fatigue-critical defect size by pulsed current parameters in GTAW-based wire arc additive manufacturing of Ti-6Al-4V

Abstract Wire arc additive manufacturing (WAAM) can suffer from lack of fusion (LoF) and gas porosity, which degrade fatigue performance. Although pulsed arc current has been widely used for defect reduction in welding, its mechanistic role in controlling molten-pool dynamics and...

Complement profiling and neutrophil single-cell analysis reveal inflammation via the classical complement pathway in Behçet’s syndrome

Behçet’s syndrome (BS) is a systemic immune-mediated disorder characterised by recurrent mucocutaneous, skin, and ocular inflammation, with severe neurological, vascular, or gastrointestinal involvement in some individuals. Although neutrophilic inflammation is considered central...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

Intratumoral Administration of Recombinant Murine Interleukin‐12 Prevents Tumor Progression and Bone Invasion

ABSTRACT Background Oral squamous cell carcinoma (OSCC) progression is accompanied by bone invasion. Therefore, maintaining oral function is necessary to regulate tumor progression. Also, interleukin-12 (IL-12), a well-known anti-tumor cytokine, can suppress osteoclast differenti...

Evaluation of joint quality and shear performance of high-frequency induction-heating riveting

This study evaluates the joint quality and shear performance of riveted joints fabricated using induction heating (IH) through experiments and simulations. Riveting specimens fabricated using three IH processes (IHA, IHB, and IHC) were compared with coke-heating (CH) specimens. T...

Angioarchitectural characterization of transdural supply in brain arteriovenous malformations: a multicenter retrospective study

Transdural supply (TDS) is a recognized angioarchitectural feature of brain arteriovenous malformations (bAVMs). We aimed to systematically characterize the angioarchitecture of TDS in bAVMs, focusing on whether transdural feeders terminated within the nidus or connected directly...

Robotic repair of an esophago–left main bronchial fistula using a pedicled autologous pericardial patch and latissimus dorsi muscle flap: a novel technique after chemoradiotherapy for cT4b esophageal cancer

Abstract Once an esophago–airway fistula develops during chemoradiotherapy for cT4b esophageal cancer, further curative treatment is often precluded. We describe a robotic technique for closure of a large esophago–left main bronchial fistula using a pedicled autologous pericardia...

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study ass...

Boundedness of Composition Operators in Orlicz–Morrey Spaces

ABSTRACT In this paper, we investigate the necessary and sufficient conditions for the boundedness of composition operators on Orlicz–Morrey spaces. Our results encompass Lebesgue and generalized Morrey spaces as special cases. In addition, we characterize the boundedness of comp...

Thermomechanical Properties of Natural Rubber/OPEFB Composites With Hybrid Latex–Starch Coupling Agent

ABSTRACT Natural rubber composites remain essential for industrial applications in Indonesia, particularly in tire manufacturing, where improved rigidity and strength are required. This study investigates the use of oil palm empty fruit bunch fiber as a sustainable filler to enha...

Comprehensive Spectroscopic Elucidation of Atomically Dispersed FeN 4 Active Sites of Fe‐N‐C Electrocatalysts

ABSTRACT To gain insights into single‐atom active sites of iron, nitrogen‐doped carbon (Fe‐N‐C), we performed comprehensive element‐specific spectroscopies including Fe K ‐edge X‐ray absorption, 57 Fe Mössbauer, and Fe Kβ 1,3 and valence‐to‐core (VtC) X‐ray emission spectroscopy...

Psychological profiles of readiness for advance care planning in super-aged Japan

Advance care planning (ACP) helps ensure that future medical care reflects individuals’ values and preferences. However, little is known about how multiple psychological characteristics combine to shape readiness for ACP, particularly in Japan. This study aimed to identify psycho...

Time-dependent queue length distribution in queues fed by K customers in a finite interval

Abstract We consider queueing models, where customers arrive according to a continuous-time binomial process on a finite interval. In this arrival process, a total of K customers arrive in the finite time interval [0, T ], where arrival times of those K customers are independent...

Supramolecular Protection–Deprotection for Switching Pore‐Surface Functionality in a Crystalline Porous Organic Salt

ABSTRACT The precise installation of highly interactive functional groups on pore surfaces remains a central challenge in crystalline porous materials since such groups often interfere with framework formation. In this study, supramolecular protection–deprotection was performed i...

Distribution and Time Trends of Refractive Errors in Japanese Spectacle Wearers

Purpose: This study aimed to estimate the distribution and temporal trends of refractive errors among spectacle wearers in Japan using a nationwide database of optical chain stores. Methods: Data from 4,525,689 individuals (53.0% women and 47.0% men; age range, 6-35 years) who pu...