Orygen

Genetic evidence for the psychosis continuum: polygenic score analysis

Background The psychosis continuum conceptualises psychotic phenomena as existing on a spectrum from subclinical experiences to psychotic disorders. Despite epidemiological and clinical evidence in support of this model, few studies have examined polygenic liability across the se...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Astrocytic activity in treatment-resistant and ultra-treatment-resistant schizophrenia

Astrocytic dysfunction has been implicated in schizophrenia, but biomarkers of astrocytic activity have shown inconsistent patterns. Studies on disease heterogeneity, specifically treatment-resistant schizophrenia (TRS) and ultra-treatment-resistant schizophrenia (UTRS) are lacki...

The economic burden of Borderline Personality Disorder: direct and indirect costs, and evidence from evaluations of interventions

Background Borderline Personality Disorder (BPD) is characterized by longstanding patterns of difficulty in functioning, and when left untreated, BPD can impose a substantial financial burden on individuals and society, in terms of higher healthcare costs as well as broader socie...

A multidisciplinary perspective on digital health interventions in schizophrenia care: Expanding the 2026 Grading of Recommendations, Assessment, Development and Evaluations guidelines

In this paper, we aim to provide a multidisciplinary and lived-experience-informed perspective on existing evidence for the utilisation of digital health interventions in schizophrenia care. We have integrated the findings from the most recent meta-analysis of digital health inte...

Optimal exercise dose in adults with chronic low back pain disorders: systematic review with dose-response network meta-analysis

Objective To quantify exercise dose-response relationships and estimate the optimal dose in adults with chronic low back pain disorders (CLBDs). Design Systematic review with random-effects model-based (non-linear) dose-response network meta-analysis. Risk of bias was assessed wi...

Profiles of clinical service use for suicide ideation and suicide attempts across Australian cultural and linguistic groups: a latent class analysis using data from the National Study of Mental Health and Wellbeing (2020–2022)

Abstract Background Suicide ideation and suicide attempts represent a public health problem in Australia, for which most people do not seek formal clinical care. However, little research currently exists on the prevalence of STB within the culturally and linguistically diverse (C...

Ensemble clustering: A practical tutorial

Abstract Cluster analysis is an explorative analytical method, serving as a critical tool in psychology, psychiatry, and related fields to map heterogeneous data into meaningful subgroups. Despite their extensive historical use, traditional clustering techniques suffer from a lac...