Ontario Institute for Cancer Research

Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site

ClpP protease maintains proteostasis in human mitochondria and is overexpressed in cancers such as acute myeloid leukemia (AML). While activators such as dordaviprone (ONC201) have reached the clinic, the development of ClpP inhibitors has been hampered by paradoxical activation...

Fast-moving consumer goods, slow-moving policy: structures and strategies of China’s e-cigarette industry and global regulatory challenges

Background China is the global centre for e-cigarette (EC) manufacturing. While regulatory responses have increasingly incorporated supply-side enforcement measures, research examining the supply-side dynamics of the global EC market remains limited. Methods Using the tobacco ind...

Smoking‐induced deprivation and subsequent smoking cessation among adults who smoke in four high‐income countries: Trends, correlates and longitudinal associations, 2016–2024

Abstract Background and aims Tobacco smoking substantially contributes to poverty. Smoking‐induced deprivation (SID) occurs when people continue smoking despite financial stress. This study examined (i) trends in SID in Canada, the United States (US), England and Australia from 2...

Awareness and use of oral tobacco and nicotine products among people who smoke or recently stopped smoking: Descriptive findings from the 2024 EASE/ITC New Zealand Survey

ABSTRACT Introduction Aotearoa New Zealand (NZ) disallows sales of oral tobacco and nicotine products, although importation for personal use is permitted. The government proposes legalising sales, claiming this will aid smoking cessation among “older, long-term smokers.” We exami...