Oncode Institute

Applying 177Lu-Dotatate for Hereditary Neuroendocrine Tumours: The Role in MEN1

Abstract Introduction Multiple endocrine neoplasia type 1 (MEN1) is the most common genetic syndrome causing neuroendocrine tumours (NET) with metastatic duodenopancreatic NET (dpNET) forming the predominant cause of MEN1-related mortality. Peptide receptor radionuclide therapy w...

Multiscale physical effects of CpG methylation on DNA mechanics, nucleosome wrapping, and chromatin condensates

DNA methylation at CpG dinucleotides is a central epigenetic modification linked to transcriptional repression and heterochromatin formation, yet its physical impact on chromatin organization remains incompletely understood. Here, we integrate single-molecule force spectroscopy,...

Psychometric properties of the Seattle–Groningen Memory Assessment in healthy adults

Brief assessments are increasingly important for scalable and accessible measurement of cognitive function. The Seattle-Groningen Memory Assessment (SGMA) is an accessible memory test that quantifies individual differences in the speed of forgetting through a computational model....

DNA end-resection is stimulated by an interaction between BRCA1 exon 11 and TOPBP1

Abstract Approximately 60% of the tumour suppressor protein BRCA1 is encoded by a single exon. Many tumours carry mutations in this exon, often resulting in exon skipping and thus a protein of a severely reduced size. Although none of the well-described protein domains of BRCA1 a...

Correlation of [ 68 Ga]Ga-RAYZ-8009 PET/CT Uptake with Immunohistochemical Glypican-3 Expression in Hepatocellular Carcinoma: A Proof-of-Target Study

Glypican-3, a cell-surface proteoglycan, is overexpressed in most hepatocellular carcinomas (HCCs). Recently, the glypican-3–targeted PET tracer [68Ga]Ga-RAYZ-8009 was shown to enable noninvasive detection of HCC. This retrospective analysis evaluates the correlation between tumo...

CPPAtools: a computation toolset for chimera protein prediction and analysis

Genetic or non-genetic frameshifting can increase the production of erroneous proteins, with far-reaching impacts on cellular phenotypes, including cancer. While the presence and impact of genetic alterations cannot be foreseen and are often defined clinically following phenotypi...

A ubiquitin chain-feeding mechanism for BRCA1-A

Abstract The BRCA1-A complex is a multi-subunit, metallo-deubiquitinating enzyme (metallo-DUB) involved in genome maintenance. BRCA1-A displays strict specificity for K63-linked ubiquitin, with a strong preference for long chains, but the mechanistic basis for this selectivity ha...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...