Ollscoil na Gaillimhe – University of Galway

Chromosomal requirements for formation of multivalent human nucleoli

Human nucleoli are multivalent, involving contributions from up to 10 NOR-bearing acrocentric chromosome p-arms. Precision megabase-scale chromosome engineering defines the requirements for this major genome organizational event. NOR deletions reveal that p-arm clustering can occ...

Téarmaí Buanchoimeádta Dhigitigh: a bilingual Irish-English glossary of digital preservation terminology

This poster describes a collaborative effort between the Digital Repository of Ireland, Gaois, Fiontar & Scoil na Gaeilge, DCU and the University of Galway to draft a standardised set of Irish language terms relating to Digital Preservation, to produce the list as a publication a...

Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications

ABSTRACT Cysteine thioaldehydes are putative intermediates in sulfatase‐maturing enzyme catalysis and in the biosynthesis of penicillin, coenzyme A and families of ribosomally synthesized and posttranslationally modified peptides (RiPPs). Norrish type‐II photolysis of phenacylsul...

The palliative care needs of adolescents and young adults with a life limiting condition: a systematic review

Adolescence and young adulthood is characterised by complex developmental and psychosocial changes. The diagnosis of a life-limiting condition adds complexity and stress to this already turbulent period of life. Provision of developmentally appropriate palliative care to this gro...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

SKY92 Identifies High‐Risk Newly Diagnosed Multiple Myeloma With Inferior Progression‐Free Survival and Implicates NUF2 as a Candidate Driver

ABSTRACT Objectives To determine the prevalence and prognostic significance of the SKY92 gene‐expression signature, evaluate minimal/measurable residual disease (MRD), and identify molecular drivers of high‐risk disease in transplant‐eligible newly diagnosed multiple myeloma (TE‐...

Examining the relationships between time pressure, challenge and hindrance technostressors and work outcomes in online labour markets

Purpose The antecedents and consequences of technostress are well documented. Yet, one aspect of the technostress process that is not well understood is the role of time in shaping perceptions of technostress. This research investigates the relationships between time pressure, te...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...

Whole-genome sequencing data confirms the uniqueness of Ireland’s native honey bee

Abstract Recent evidence suggests a rise in the importation of non-native honey bee subspecies into Ireland with an associated potential rise in hybridisation followed by introgression. The purity of the Apis mellifera mellifera (A. m. mellifera) population in Ireland, given its...