Olgahospital

Combined interleukin-1 blockade for central nervous system inflammation in children with severe cryopyrin-associated periodic syndromes

Cryopyrin-associated periodic syndromes (CAPS) are rare NLRP3-mediated autoinflammatory disorders driven by excessive interleukin-1 (IL-1) signalling [1]. Central nervous system (CNS) inflammation, including aseptic meningitis, papilledema and sensorineural hearing loss, characte...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...