Oklahoma City VA Medical Center

PFKFB2 Gates a Relationship Between Cardiac Glycolytic Regulation and Electrophysiological Function

Abstract Background The cardiac isoform of phosphofructokinase-2/fructose 2,6-bisphosphatase (PFKFB2) is the heart’s strongest glycolytic regulator but is degraded in the absence of insulin signaling. This makes PFKFB2 loss critical to understand in metabolic heart disease, of wh...