Okayama University Hospital

Periodontitis and infertility: a critical narrative review with qualitative synthesis and an author-proposed translational roadmap for preconception periodontal research

Periodontitis is a chronic dysbiotic inflammatory disease that may increase systemic inflammatory burden and expose distant organs to microbial products. Clinical and experimental studies suggest possible associations with reproductive dysfunction, but causality and the effect of...

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

Abstract Background In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Methods Pat...

Shall we score? The SHALL-WE score for optimizing sclerotherapy in superficial lymphatic malformations

No standardized tool guides the decision of when to escalate beyond sclerotherapy in lymphatic malformations (LMs). We developed the SHALL-WE score (Severity, Histology, And Location—Lymphatic malformation: When to Escalate) to define the optimal sclerotherapy threshold in superf...

Two postnatal mouse models with Pth1r deletion reproduce limb phenotype for Blomstrand chondrodysplasia

Blomstrand chondrodysplasia (BOCD) is a lethal autosomal recessive disorder characterized by skeletal and facial deformity and caused by loss-of-function variants in the parathyroid hormone 1 receptor gene ( PTH1R ). Because BOCD results in embryonic lethality in humans, animal m...

Demographic and clinical characteristics of rapidly progressive glomerulonephritis in renal vasculitis in the Japan renal biopsy registry

This study evaluated the clinical and demographic characteristics of biopsy-proven rapidly progressive glomerulonephritis (RPGN), with histological evidence of renal vasculitis. We focused on five vasculitis-related nephritides: MPO-ANCA, PR3-ANCA, anti-GBM, IgA vasculitis (IgAV)...

Mechanosensitive Stanniocalcin-1 Suppresses Pulmonary Artery Smooth Muscle Cell Proliferation and Attenuates Experimental Pulmonary Hypertension

BACKGROUND: Idiopathic pulmonary arterial hypertension (IPAH) is driven by progressive vascular remodeling, particularly smooth muscle cell (SMC) proliferation. Current combination vasodilator therapies have markedly improved outcomes; however, prognosis remains poor in subgroups...

Effect of operator experience level on clinical outcomes of indirect- and direct-bonding techniques: A single-center, open-label, quasi-randomized controlled clinical trial

Objective: This study aimed to compare the clinical outcomes of indirect- and direct-bonding techniques for bracket placement in orthodontic treatment, focusing on the influence of operator experience. Methods: A total of 153 patients were quasi-randomly assigned to the indirect-...

De-escalation of perioperative systemic therapy for early breast cancer.

Breast cancer is the most common malignancy among women worldwide, and the number of survivors continues to increase owing to earlier detection and advances in treatment. As long-term survivorship becomes increasingly important, minimizing treatment-related toxicity without compr...

Nivolumab plus ipilimumab-based treatment in Japanese patients with metastatic non-small cell lung cancer and tumor PD-L1 < 1%: a pooled analysis

BACKGROUND: Nivolumab plus ipilimumab-based therapies have shown long-term, durable clinical benefit in patients with metastatic non-small cell lung cancer (NSCLC), including those with tumor programmed death-ligand 1 (PD-L1) expression < 1%, a population with high unmet need. He...