Oita University

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

Abstract While nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard second-line regimen for unresectable pancreatic cancer (uPC) after gemcitabine-based therapy, the effects of initial dosing and relative dose intensity (RDI) in routine practice are unc...

Rheumatoid arthritis-associated peptidylarginine deiminase 4 haplotype citrullinates human immunodeficiency virus-pol and confers antiviral activity

Peptidylarginine deiminase 4 (PADI4)-mediated citrullination modulates immune responses and drives autoantibody formation in rheumatoid arthritis (RA). Two common haplotypes, defined by four exonic SNPs ( PADI4_89 , 90 , 92 , and 104 ), have been described, with haplotype 2 (the...