Oita University

Impact of artificial stocking and its intensity on genetic diversity, genetic structure, and effective number of breeders in masu salmon Oncorhynchus masou

Artificial stocking, an important tool in fishery resource enhancement and wildlife management, exerts negative effects on wild conspecifics. However, the factors determining the magnitude of these effects remain unclear. Here, we investigated how stocking influences genetic dive...

Commit-Window Observation Contracts for Reactive Entity-Component Systems

Modern entity-component systems (ECS) runtimes expose structural events (OnAdd, OnSet, and OnRemove), change filters, and continuous queries (CQ) so that systems rerun only where data changed; yet the correctness of the underlying optimizations—coalescing notifications, reorderin...

Association between daily drainage volume and subsequent lymphedema after inguinal lymph node dissection for skin cancer

Abstract Background: Inguinal lymph node dissection (ILND) is essential for regional control of skin cancers but is frequently complicated by postoperative lymphedema (LE). However, early clinical indicators associated with subsequent LE development after ILND remain insufficient...

Mechanosensitive Stanniocalcin-1 Suppresses Pulmonary Artery Smooth Muscle Cell Proliferation and Attenuates Experimental Pulmonary Hypertension

BACKGROUND: Idiopathic pulmonary arterial hypertension (IPAH) is driven by progressive vascular remodeling, particularly smooth muscle cell (SMC) proliferation. Current combination vasodilator therapies have markedly improved outcomes; however, prognosis remains poor in subgroups...

Hemoglobin-dependent differences in the antioxidant properties of uric acid and albumin: an in vitro analysis

Abstract Background Oxidative stress is a major contributor to morbidity in patients with end-stage kidney disease. The antioxidant properties of vitamin E–coated hemodialyzers have attracted increasing attention. However, the intrinsic antioxidant capacity of dialysis-related su...

Akhirin Preserves Hemostatic Wound Repair Through Non-Hematopoietic Regulation of the Vascular Injury Microenvironment

Hemostasis and wound healing are highly coordinated processes that involve rapid clot formation followed by controlled remodeling of the injured tissue microenvironment. Prior work on Akhirin (AKH), a secreted extracellular matrix protein containing two von Willebrand factor A do...

High-temperature-treated soy protein isolate reduces amino acid availability and alters social novelty in mice

Abstract High-temperature (HT) treatments above 100 °C are important in food processing; however, their effects on the nutritional value of moist heat-treated proteins are less understood. Therefore, this study examined the impact of HT at 121 °C on soy protein isolate (SPI) in w...

Safety of Endoscopic Ultrasound-Guided Biliary Drainage in Patients with Distal Malignant Biliary Obstruction with Large-Volume Ascites

Background/Aims: The safety and efficacy of endoscopic ultrasound-guided biliary drainage (EUS-BD) in patients with large-volume ascites (LVA) remain unclear. We aimed to evaluate the safety of EUS-BD in patients with distal malignant biliary obstruction complicated by LVA. Metho...

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study ass...

Histological Determinants of Atrial Dysfunction in Patients With Atrial Fibrillation

Background Atrial fibrillation (AF) is associated with diverse histological abnormalities, but their contributions to atrial dysfunction and functional recovery remain unclear. Methods In a discovery cohort of 375 patients with nonvalvular AF undergoing catheter ablation, atrial...

The First Whole-Genome Characterization of a Kenyan DS-1-like G3P[8] Rotavirus Strain: Evidence for an Intragenogroup Reassortment Event in Africa

Unusual DS-1-like G3P[8] rotavirus strains have emerged and spread rapidly across several countries. In Africa, however, reports of these strains and available whole-genome data remain limited, and their evolutionary relationships across the continent are not yet fully understood...

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

Abstract While nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard second-line regimen for unresectable pancreatic cancer (uPC) after gemcitabine-based therapy, the effects of initial dosing and relative dose intensity (RDI) in routine practice are unc...

Rheumatoid arthritis-associated peptidylarginine deiminase 4 haplotype citrullinates human immunodeficiency virus-pol and confers antiviral activity

Peptidylarginine deiminase 4 (PADI4)-mediated citrullination modulates immune responses and drives autoantibody formation in rheumatoid arthritis (RA). Two common haplotypes, defined by four exonic SNPs ( PADI4_89 , 90 , 92 , and 104 ), have been described, with haplotype 2 (the...