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Altered thalamo–prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition

ABSTRACT Schizophrenia is associated with profound working memory deficits, for which there are no approved treatments. Rare heterozygous null mutations in SETD1A , a gene encoding a key epigenetic regulatory protein, have been definitively linked to increased risk for schizophre...

Induced proximity-based therapeutics for advanced prostate cancer

Abstract Metastatic castration-resistant prostate cancers (mCRPC) remain dependent on androgen receptor (AR) signaling despite resistance to androgen-deprivation and AR-targeted therapies. Induced proximity-based therapeutics employ event-driven pharmacology to target AR, potenti...

Using the NIH Research Methods Resources Website

The Research Methods Resources (RMR) section of the National Institutes of Health (NIH) website provides information on design, analysis, and sample size for designs used in NIH-supported clinical trials including randomized controlled trials, individually randomized group-treatm...