Office of Readiness and Response

A Multistate Investigation of Serious Adverse Events, including Deaths, following Ceftriaxone Injections, September 2024–August 2025

BACKGROUND: Reports of ceftriaxone serious adverse events (SAEs), including deaths, from multiple jurisdictions during December 2024-January 2025 prompted a nationwide investigation to evaluate product safety, characterize SAEs, and assess for changes in baseline adverse event oc...

An ecological time-series study of heat-related illness in Honolulu County, Hawaiʻi: implications for heat preparedness and public health response

Heat-related illness (HRI) is a growing public health concern. HRI risk in Hawaiʻi has not previously been reviewed to determine the risks of heat on public health and well-being. This study summarizes HRI in Honolulu County and evaluates the relationship between local daily heat...

Concordance of genetic determinants of acute coronary artery disease between European and Chinese populations

AIMS: This study examined the concordance of associations of single nucleotide polymorphisms (SNPs) for acute coronary artery disease (CAD) discovered in Europeans with acute CAD, chronic ischaemic heart disease (IHD) or stroke in Chinese adults. METHODS: In a nested case-control...

Operationalizing public health emergency operations centers in Somalia: a scoping review of challenges and strategies

Public Health Emergency Operations Centers (PHEOCs) are central to national health security systems, enabling coordinated preparedness, surveillance, and response to public health emergencies. However, their operationalization remains particularly challenging in fragile and confl...