Occupational Cancer Research Centre

Exclusive and Any Breastfeeding, Infant Formula Feeding, and Childhood Growth

OBJECTIVES: To understand the association between exclusive breastfeeding, any breastfeeding, and infant formula feeding and childhood growth. METHODS: A longitudinal cohort study was conducted among children from birth up to 10 years in Toronto, Canada. The primary exposure was...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

20 Updates on Magnetic Resonance Imaging assessment of tumour MicrOStructure in GlioblastomA: A cross-sectional study (The MIMOSA Study)

Abstract The MIMOSA (Magnetic Resonance Imaging assessment of tumour MicrOStructure in GlioblastomA) study is recruiting patients with a presumed diagnosis of glioblastoma (GBM) pre-operatively to receive advanced diffusion-weighted magnetic-resonance-imaging (DW-MRI) using the C...

Cell‐Type‐Resolved Proteomics Reveals Distinct Immune and Metabolic Programs Between Primary and Recurrent Ascites in HGSOC

ABSTRACT High‐grade serous ovarian carcinoma (HGSOC) frequently recurs after platinum–taxane therapy, yet recurrence‐associated changes within ascites remain unclear. We performed cell‐type‐resolved quantitative proteomics on paired ascites samples collected at primary diagnosis...

Molecular characterization of mismatch repair deficient tumors in young Jordanian patients

<title>Abstract</title> In Jordan, approximately 19% of colorectal carcinomas (CRCs) in patients younger than 45 years show mismatch repair deficiency (MMRD) by immunohistochemistry (IHC). MMRD in pediatric high-grade gliomas (HGG) and CRC in Jordan appears substantially more fre...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...