Obstetrics and Gynecology Hospital of Fudan University

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

ABSTRACT Lactate is no longer viewed simply as a glycolytic end‐product, but as a compartmentalized signaling metabolite that coordinates energy production, carbon redistribution, redox balance, and anabolic commitment. This review discusses lactate as a regulator of the cataboli...

Organic–Inorganic Dual‐Nanofiber Interpenetrating Network Scaffolds for Complementary Enhancement of Mechanical Stability and Osteogenic Bioactivity

ABSTRACT Incorporating nanofibers into 3D‐printed scaffolds is an effective strategy to enhance the physicochemical properties and osteogenic bioactivity of bone tissue engineering constructs. In this study, we developed a composite scaffold featuring a dual‐nanofiber interpenetr...

Dydrogesterone and LNG-IUS for preventing postoperative recurrence after hysteroscopic surgery in patients with endometrial polyps and simple endometrial hyperplasia: a retrospective cohort study

Abstract Background Endometrial polyps (EPs) and non-atypical endometrial hyperplasia (EH) frequently cause abnormal uterine bleeding in reproductive-aged women. While hysteroscopy resects macroscopic lesions, postoperative recurrence is prevalent; progestogen therapy may mitigat...

Transient Neonatal Uterine Bleeding Offers a Window to Understanding Uterine Development

The phenomenon of neonatal uterine bleeding was observed over centuries. It was dismissed as having no clinical relevance. Alternatively, it was hypothesized to be associated with early-onset endometriosis, but its exact clinical significance remains unknown. We conducted a narra...

Klebsiella pneumoniae-associated prostatic and bilateral seminal vesicle abscesses: a case report

Prostatic abscess is uncommon and potentially life-threatening. Simultaneous involvement of the prostate and both seminal vesicles is particularly rare. A 79-year-old Chinese man with poorly controlled type 2 diabetes mellitus, benign prostatic hyperplasia, and prostatic calcific...

Safety and satisfaction of voluntary medical male circumcision among men who have sex with men in China

PURPOSE: To investigate the safety and satisfaction of circumcision among men who have sex with men (MSM), as voluntary male medical circumcision (VMMC) may be an innovative and acceptable tool for HIV prevention among this population in the future. METHODS: Participants who volu...

Butterfly Proboscis‐Inspired Water‐Welding Strategy for Hollow‐Walled Hydrogel 3D Stents With Ultrahigh Mechanical Support Capacity

ABSTRACT Hydrogels have emerged as promising candidates for next‐generation implantable biomedical stents. However, the scalable fabrication of hydrogel three‐dimensional (3D) stents with sufficient mechanical support remains a major challenge, owing to the intrinsic flexibility...

Development and internal validation of an early pre-sleep prediction model for first-night postoperative sleep disturbance: a prospective cohort study

Abstract Background Postoperative sleep disturbance (PSD) is common and may impair recovery. Sleep quality during the first postoperative night is important in early recovery and offers an immediate opportunity for symptom-directed care. Several PSD prediction models have been re...

Association of prenatal noise exposure with postpartum depressive symptoms and self-harm ideation

Environmental noise is a pervasive but understudied determinant of perinatal mental health. We investigated whether prenatal residential noise exposure was associated with postpartum depressive symptoms and clinically documented self-harm ideation, thereby extending evidence beyo...

Higher eGFRdiff is associated with increased risk of rapid kidney function decline in hypertensive individuals

Abstract Background Hypertensive nephropathy is the second contributing factor to end-stage renal disease, while the relationship between the difference between estimated glomerular filtration rates (eGFRdiff) and rapid kidney function decline (RKFD) in hypertensive patients rema...

Acox2 deficiency induces cardiac dysfunction via cross-organ metabolic reprogramming in mice

Abstract Background Secondary cardiomyopathies are a major cause of heart failure (HF) with diverse etiologies and high mortality rates. For example, over 50% of patients with end-stage liver disease develop cardiac dysfunction, clinically termed cirrhotic cardiomyopathy (CCM). W...