Obafemi Awolowo University Teaching Hospitals Complex

Oxidative Stress Burden in Paediatric Sickle Cell Anaemia: Effects of Hydroxyurea Therapy, Disease Severity, and Socioeconomic Factors

Background: Oxidative stress plays a central role in the pathophysiology of sickle cell anaemia (SCA), contributing to haemolysis, endothelial dysfunction, and disease complications.Hydroxyurea (HU), the main disease-modifying therapy for SCA, may influence oxidative balance; how...

Self-reported Hypertension, Awareness, Knowledge, and Risk-related Lifestyle Factors among Final-year University Students in Enugu, Nigeria: A Cross-sectional Study

Background Hypertension is a leading cause of cardiovascular morbidity and mortality worldwide and is increasingly recognized among young adults. University students are often exposed to risk-related behaviours such as physical inactivity, unhealthy diets, alcohol and caffeine in...

Correlation of modified Thyroidectomy Difficulty Scale with postoperative outcomes following thyroidectomy for multinodular euthyroid goiters in a tertiary hospital, southwest Nigeria

ABSTRACT Background: In Nigeria, many patients present late with large goiter with attendant intraoperative challenges. Complications following thyroidectomy can sometimes be life-threatening or may be associated with significant morbidity. The ability to intraoperatively identif...

Parental perception and intention to vaccinate female children 9–14 years with the human papillomavirus vaccine in Ile-Ife, Nigeria: theory of planned behaviour approach

Human papillomavirus (HPV) vaccination is a highly effective strategy for preventing cervical cancer; however, achieving high vaccination coverage among eligible girls depends largely on parental decision-making. This study assessed parental perceptions and intention to vaccinate...

Safety of Day Case Percutaneous Liver Biopsies at a Tertiary Hospital in Nigeria

Abstract Background: Percutaneous liver biopsy (PLB) is a procedure through which liver tissue is obtained for making the diagnosis of liver diseases. Most PLBs are performed as a day case procedure, and complications can occur. Objective: This study assessed the safety of PLBs a...

Diagnostic dilemma in the management of a cervical spinal cord lesion: neuromyelitis optica spectrum disorder: a case report

Abstract Background Neuromyelitis optica spectrum disorder, known eponymously as Devic’s disease, is a condition in which antibodies are elaborated against aquaporin water channels in the end foot processes of astrocytes due to autoimmune dysregulation thereby initiating a cascad...

Parental and health service-related factors influencing full pentavalent vaccine uptake among children aged 12-23 months in Nigeria: findings from the demographic and health survey

Recurrent diphtheria outbreaks in Sub-Saharan African countries remain a major public health concern, which have been related with suboptimal pentavalent vaccine uptake. Nationally representative evidence on full pentavalent vaccine uptake and its determinants in Nigeria remains...

Perceived stress, dental pain, and coping strategies among dental patients in Nigeria: a cross-sectional study

Perceived stress reflects an individual’s appraisal of a situation as overwhelming. It plays a crucial role in shaping pain experience and management. Dental pain, resulting from tooth decay, its sequelae or periodontal diseases, may adversely affect quality of life by contributi...